Seroatlas · Human Serome Atlas

KCTD2

BTB/POZ domain-containing protein KCTD2

Also known as: KCTD2_HUMAN, KIAA0176

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14681
Gene: KCTD2
Ensembl: ENSG00000180901
Chromosome: 17
Canonical length: 263 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cullin family protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>Q14681|KCTD2
     1  MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA VAQPLEPGPG
    61  PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR LCCQEDPELD SDKDETGAYL
   121  IDRDPTYFGP ILNYLRHGKL IITKELAEEG VLEEAEFYNI ASLVRLVKER IRDNENRTSQ
   181  GPVKHVYRVL QCQEEELTQM VSTMSDGWKF EQLISIGSSY NYGNEDQAEF LCVVSRELNN
   241  STNGIVIEPS EKAKILQERG SRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 10 nTPM
cerebral cortex: 4.3 nTPM
skeletal muscle: 3.2 nTPM
adipose tissue: 2.8 nTPM
spinal cord: 2.3 nTPM
testis: 1.6 nTPM

Single-cell type

cardiomyocytes: 194 nCPM
choroid plexus epithelial cells: 175 nCPM
retinal bipolar cells: 67 nCPM
myonuclei: 65 nCPM
retinal pigment epithelial cells: 51 nCPM
ependymal cells: 50 nCPM

Immune cell

NK-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 75 nTPM
cerebral cortex: 53 nTPM
spinal cord: 50 nTPM
thalamus: 49 nTPM
white matter: 48 nTPM
basal ganglia: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0.2
gnomAD missense Z: 1.72
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCTD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GNG2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD2 as an antibody target. Whether an autoantibody or antibody against KCTD2 could matter depends on whether native KCTD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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