Seroatlas · Human Serome Atlas

ZBTB16

Zinc finger and BTB domain-containing protein 16

Also known as: PLZF, ZBT16_HUMAN, ZNF145

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q05516
Gene
ZBTB16
Ensembl
ENSG00000109906
Chromosome
11
Canonical length
673 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

673 residues, UniProt reviewed canonical sequence.

>Q05516|ZBTB16
     1  MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT VLACTSKMFE
    61  ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD DLLYAAEILE IEYLEEQCLK
   121  MLETIQASDD NDTEATMADG GAEEEEDRKA RYLKNIFISK HSSEESGYAS VAGQSLPGPM
   181  VDQSPSVSTS FGLSAMSPTK AAVDSLMTIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE
   241  VKTEMMQVDE VPSQDSPGAA ESSISGGMGD KVEERGKEGP GTPTRSSVIT SARELHYGRE
   301  ESAEQVPPPA EAGQAPTGRP EHPAPPPEKH LGIYSVLPNH KADAVLSMPS SVTSGLHVQP
   361  ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKSESR TIGEQCSVCG VELPDNEAVE
   421  QHRKLHSGMK TYGCELCGKR FLDSLRLRMH LLAHSAGAKA FVCDQCGAQF SKEDALETHR
   481  QTHTGTDMAV FCLLCGKRFQ AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH
   541  TGDHPYECEF CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK
   601  PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK GHKPEEIPPD
   661  WRIEKTYLYL CYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 76 nTPM
  • blood vessel: 66 nTPM
  • skeletal muscle: 63 nTPM
  • pancreas: 52 nTPM
  • adipose tissue: 47 nTPM
  • urinary bladder: 30 nTPM

Single-cell type

  • thymic myoid cells: 2,005 nCPM
  • myonuclei: 1,909 nCPM
  • proximal tubule cells: 1,551 nCPM
  • prostatic glandular cells: 1,515 nCPM
  • renal collecting duct intercalated cells: 1,117 nCPM
  • pituicytes/fscs: 863 nCPM

Immune cell

  • MAIT T-cell: 38 nTPM
  • gdT-cell: 23 nTPM
  • naive B-cell: 11 nTPM
  • NK-cell: 10 nTPM
  • total PBMC: 5.4 nTPM
  • classical monocyte: 4.2 nTPM

Brain region

  • medulla oblongata: 71 nTPM
  • cerebral cortex: 71 nTPM
  • white matter: 65 nTPM
  • pons: 62 nTPM
  • basal ganglia: 58 nTPM
  • hypothalamus: 57 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZBTB16.

Disease | AllUniProt

Conditions ZBTB16 is implicated in, by any mechanism.

  • Skeletal defects, genital hypoplasia, and impaired intellectual development (SGYMR) MIM:612447

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.47
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB16 as an antibody target. Whether an autoantibody or antibody against ZBTB16 could matter depends on whether native ZBTB16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZBTB16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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