Seroatlas · Human Serome Atlas

ZBTB10

Zinc finger and BTB domain-containing protein 10

Also known as: FLJ12752, RINZF, ZBT10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DT7
Gene: ZBTB10
Ensembl: ENSG00000205189
Chromosome: 8
Canonical length: 871 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables telomeric DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in chromosome, telomeric region and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

871 residues, UniProt reviewed canonical sequence.

>Q96DT7|ZBTB10
     1  MSFSEMNRRT LAFRGGGLVT ASGGGSTNNN AGGEASAWPP QPQPRQPPPP APPALQPPNG
    61  RGADEEVELE GLEPQDLEAS AGPAAGAAEE AKELLLPQDA GGPTSLGGGA GGPLLAERNR
   121  RTLAFRGGGG GGLGNNGSSR GRPETSVWPL RHFNGRGPAT VDLELDALEG KELMQDGASL
   181  SDSTEDEEEG ASLGDGSGAE GGSCSSSRRS GGDGGDEVEG SGVGAGEGET VQHFPLARPK
   241  SLMQKLQCSF QTSWLKDFPW LRYSKDTGLM SCGWCQKTPA DGGSVDLPPV GHDELSRGTR
   301  NYKKTLLLRH HVSTEHKLHE ANAQESEIPS EEGYCDFNSR PNENSYCYQL LRQLNEQRKK
   361  GILCDVSIVV SGKIFKAHKN ILVAGSRFFK TLYCFSNKES PNQNNTTHLD IAAVQGFSVI
   421  LDFLYSGNLV LTSQNAIEVM TVASYLQMSE VVQTCRNFIK DALNISIKSE APESVVVDYN
   481  NRKPVNRDGL SSSRDQKIAS FWATRNLTNL ASNVKIENDG CNVDEGQIEN YQMNDSSWVQ
   541  DGSPEMAENE SEGQTKVFIW NNMGSQGIQE TGKTRRKNQT TKRFIYNIPP NNETNLEDCS
   601  VMQPPVAYPE ENTLLIKEEP DLDGALLSGP DGDRNVNANL LAEAGTSQDG GDAGTSHDFK
   661  YGLMPGPSND FKYGLIPGTS NDFKYGLIPG ASNDFKYGLL PESWPKQETW ENGESSLIMN
   721  KLKCPHCSYV AKYRRTLKRH LLIHTGVRSF SCDICGKLFT RREHVKRHSL VHKKDKKYKC
   781  MVCKKIFMLA ASVGIRHGSR RYGVCVDCAD KSQPGGQEGV DQGQDTEFPR DEEYEENEVG
   841  EADEELVDDG EDQNDPSRWD ESGEVCMSLD D

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 22 nTPM
liver: 17 nTPM
placenta: 17 nTPM
pancreas: 13 nTPM
prostate: 13 nTPM
fallopian tube: 11 nTPM

Single-cell type

endometrial glandular cells: 179 nCPM
endometrial luminal cells: 175 nCPM
melanocytes: 132 nCPM
syncytiotrophoblasts: 130 nCPM
salivary acinar cells: 109 nCPM
prostatic glandular cells: 108 nCPM

Immune cell

plasmacytoid DC: 0.9 nTPM
NK-cell: 0.5 nTPM
naive B-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM

Brain region

cerebellum: 34 nTPM
white matter: 20 nTPM
hypothalamus: 20 nTPM
basal ganglia: 19 nTPM
medulla oblongata: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.99
gnomAD missense Z: 2.02
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

IPO8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB10 as an antibody target. Whether an autoantibody or antibody against ZBTB10 could matter depends on whether native ZBTB10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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