Seroatlas · Human Serome Atlas

CCIN

Calicin

Also known as: BTBD20, CALI_HUMAN, KBTBD14

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13939
Gene: CCIN
Ensembl: ENSG00000185972
Chromosome: 9
Canonical length: 588 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Perinuclear theca,Calyx

OverviewNCBI Gene

The protein encoded by this gene is a basic protein of the sperm head cytoskeleton. This protein contains kelch repeats and a BTB/POZ domain and is necessary for normal morphology during sperm differentiation. This gene is intronless. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

588 residues, UniProt reviewed canonical sequence.

>Q13939|CCIN
     1  MKLEFTEKNY NSFVLQNLNR QRKRKEYWDM ALSVDNHVFF AHRNVLAAVS PLVRSLISSN
    61  DMKTADELFI TIDTSYLSPV TVDQLLDYFY SGKVVISEQN VEELLRGAQY FNTPRLRVHC
   121  NDFLIKSICR ANCLRYLFLA ELFELKEVSD VAYSGIRDNF HYWASPEGSM HFMRCPPVIF
   181  GRLLRDENLH VLNEDQALSA LINWVYFRKE DREKYFKKFF NYINLNAVSN KTLVFASNKL
   241  VGMENTSSHT TLIESVLMDR KQERPCSLLV YQRKGALLDS VVILGGQKAH GQFNDGVFAY
   301  IIQENLWMKL SDMPYRAAAL SATSAGRYIY ISGGTTEQIS GLKTAWRYDM DDNSWTKLPD
   361  LPIGLVFHTM VTCGGTVYSV GGSIAPRRYV SNIYRYDERK EVWCLAGKMS IPMDGTAVIT
   421  KGDRHLYIVT GRCLVKGYIS RVGVVDCFDT STGDVVQCIT FPIEFNHRPL LSFQQDNILC
   481  VHSHRQSVEI NLQKVKASKT TTSVPVLPNS CPLDVSHAIC SIGDSKVFVC GGVTTASDVQ
   541  TKDYTINPNA FLLDQKTGKW KTLAPPPEAL DCPACCLAKL PCKILQRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

testis: 70 nTPM
smooth muscle: 1.7 nTPM
bone marrow: 1.3 nTPM
endometrium: 1 nTPM
cervix: 0.6 nTPM
placenta: 0.5 nTPM

Single-cell type

early spermatids: 1,121 nCPM
late spermatids: 305 nCPM
late primary spermatocytes: 230 nCPM
hepatic stellate cells: 6.5 nCPM
decidual stromal cells: 2.2 nCPM
peritubular myoid cells: 2 nCPM

Immune cell

myeloid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 1.3 nTPM
amygdala: 1.1 nTPM
basal ganglia: 1.1 nTPM
white matter: 0.8 nTPM
cerebellum: 0.6 nTPM
hippocampal formation: 0.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCIN.

Disease | AllUniProt

Conditions CCIN is implicated in, by any mechanism.

Spermatogenic failure 91 (SPGF91) MIM:620838

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 82 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure 91

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.12
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCIN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CYLC1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCIN as an antibody target. Whether an autoantibody or antibody against CCIN could matter depends on whether native CCIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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