Seroatlas · Human Serome Atlas

KEAP1

Kelch-like ECH-associated protein 1

Also known as: INrf2, KEAP1_HUMAN, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14145
Gene
KEAP1
Ensembl
ENSG00000079999
Chromosome
19
Canonical length
624 aa
Protein class
Cancer-related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centriolar satellite,Cytosol

OverviewNCBI Gene

This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

624 residues, UniProt reviewed canonical sequence.

>Q14145|KEAP1
     1  MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT
    61  KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM
   121  EVVSIEGIHP KVMERLIEFA YTASISMGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD
   181  PSNAIGIANF AEQIGCVELH QRAREYIYMH FGEVAKQEEF FNLSHCQLVT LISRDDLNVR
   241  CESEVFHACI NWVKYDCEQR RFYVQALLRA VRCHSLTPNF LQMQLQKCEI LQSDSRCKDY
   301  LVKIFEELTL HKPTQVMPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSDG TWLRLADLQV
   361  PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCAPMS VPRNRIGVGV
   421  IDGHIYAVGG SHGCIHHNSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG
   481  TNRLNSAECY YPERNEWRMI TAMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE
   541  TETWTFVAPM KHRRSALGIT VHQGRIYVLG GYDGHTFLDS VECYDPDTDT WSEVTRMTSG
   601  RSGVGVAVTM EPCRKQIDQQ NCTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KEAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
171 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 171 nTPM
  • tongue: 71 nTPM
  • liver: 59 nTPM
  • heart muscle: 58 nTPM
  • esophagus: 54 nTPM
  • spinal cord: 52 nTPM

Single-cell type

  • esophageal apical cells: 85 nCPM
  • esophageal basal cells: 78 nCPM
  • late spermatids: 78 nCPM
  • megakaryocytes: 74 nCPM
  • esophageal suprabasal cells: 63 nCPM
  • thymic myoid cells: 57 nCPM

Immune cell

  • gdT-cell: 55 nTPM
  • MAIT T-cell: 53 nTPM
  • memory CD8 T-cell: 52 nTPM
  • T-reg: 50 nTPM
  • myeloid DC: 46 nTPM
  • NK-cell: 43 nTPM

Brain region

  • white matter: 67 nTPM
  • cerebellum: 56 nTPM
  • medulla oblongata: 56 nTPM
  • basal ganglia: 55 nTPM
  • midbrain: 53 nTPM
  • pons: 52 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.63
gnomAD pLI
0
gnomAD missense Z
3.8
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KEAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KEAP1 as an antibody target. Whether an autoantibody or antibody against KEAP1 could matter depends on whether native KEAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KEAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KEAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KEAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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