Seroatlas · Human Serome Atlas

KLHL5

Kelch-like protein 5

Also known as: KLHL5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PQ7
Gene
KLHL5
Ensembl
ENSG00000109790
Chromosome
4
Canonical length
755 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Microtubules

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in microtubule cytoskeleton and plasma membrane. Implicated in cocaine dependence. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

755 residues, UniProt reviewed canonical sequence.

>Q96PQ7|KLHL5
     1  MNVIYFPLHI FVVYSRAYTS LVLVGCTNLC AVLFARCLDD HLVSLRMSGS RKEFDVKQIL
    61  KIRWRWFGHQ ASSPNSTVDS QQGEFWNRGQ TGANGGRKFL DPCSLQLPLA SIGYRRSSQL
   121  DFQNSPSWPM ASTSEVPAFE FTAEDCGGAH WLDRPEVDDG TSEEENESDS SSCRTSNSSQ
   181  TLSSCHTMEP CTSDEFFQAL NHAEQTFKKM ENYLRHKQLC DVILVAGDRR IPAHRLVLSS
   241  VSDYFAAMFT NDVREARQEE IKMEGVEPNS LWSLIQYAYT GRLELKEDNI ECLLSTACLL
   301  QLSQVVEACC KFLMKQLHPS NCLGIRSFAD AQGCTDLHKV AHNYTMEHFM EVIRNQEFVL
   361  LPASEIAKLL ASDDMNIPNE ETILNALLTW VRHDLEQRRK DLSKLLAYIR LPLLAPQFLA
   421  DMENNVLFRD DIECQKLIME AMKYHLLPER RPMLQSPRTK PRKSTVGTLF AVGGMDSTKG
   481  ATSIEKYDLR TNMWTPVANM NGRRLQFGVA VLDDKLYVVG GRDGLKTLNT VECYNPKTKT
   541  WSVMPPMSTH RHGLGVAVLE GPMYAVGGHD GWSYLNTVER WDPQARQWNF VATMSTPRST
   601  VGVAVLSGKL YAVGGRDGSS CLKSVECFDP HTNKWTLCAQ MSKRRGGVGV TTWNGLLYAI
   661  GGHDAPASNL TSRLSDCVER YDPKTDMWTA VASMSISRDA VGVCLLGDKL YAVGGYDGQA
   721  YLNTVEAYDP QTNEWTQVAP LCLGRAGACV VTVKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • seminal vesicle: 62 nTPM
  • midbrain: 49 nTPM
  • spinal cord: 49 nTPM
  • colon: 43 nTPM
  • smooth muscle: 43 nTPM
  • amygdala: 41 nTPM

Single-cell type

  • microglia: 371 nCPM
  • retinal amacrine cells: 342 nCPM
  • retinal horizontal cells: 218 nCPM
  • platelets: 216 nCPM
  • innate lymphoid cells: 210 nCPM
  • extravillous trophoblasts: 186 nCPM

Immune cell

  • basophil: 5.5 nTPM
  • memory B-cell: 5.2 nTPM
  • naive B-cell: 3.9 nTPM
  • intermediate monocyte: 3.2 nTPM
  • myeloid DC: 2.5 nTPM
  • neutrophil: 2.5 nTPM

Brain region

  • spinal cord: 84 nTPM
  • thalamus: 81 nTPM
  • medulla oblongata: 77 nTPM
  • amygdala: 77 nTPM
  • basal ganglia: 75 nTPM
  • white matter: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0
gnomAD missense Z
1.94
DepMap mean gene effect
0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL5 as an antibody target. Whether an autoantibody or antibody against KLHL5 could matter depends on whether native KLHL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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