Seroatlas · Human Serome Atlas

KLHL10

Kelch-like protein 10

Also known as: FLJ32662, KLH10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6JEL2
Gene
KLHL10
Ensembl
ENSG00000161594
Chromosome
17
Canonical length
608 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Mid piece

OverviewNCBI Gene

The protein encoded by this gene belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain a BACK domain and six C-terminal kelch repeats. Kelch domains are thought to form a four stranded beta-sheet blade structure that can fold into a beta-propeller domain when multiple kelch repeats are found together. Mutations in this gene have been associated with oligozoospermia in some infertile males. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

608 residues, UniProt reviewed canonical sequence.

>Q6JEL2|KLHL10
     1  MEMESAAAST RFHQPHMERK MSAMACEIFN ELRLEGKLCD VVIKVNGFEF SAHKNILCSC
    61  SSYFRALFTS GWNNTEKKVY NIPGISPDMM KLIIEYAYTR TVPITPDNVE KLLAAADQFN
   121  IMGIVRGCCE FLKSELCLDN CIGICKFTDY YYCPELRQKA YMFILHNFEE MVKVSAEFLE
   181  LSVTELKDII EKDELNVKQE DAVFEAILKW ISHDPQNRKQ HISILLPKVR LALMHAEYFM
   241  NNVKMNDYVK DSEECKPVII NALKAMYDLN MNGPSNSDFT NPLTRPRLPY AILFAIGGWS
   301  GGSPTNAIEA YDARADRWVN VTCEEESPRA YHGAAYLKGY VYIIGGFDSV DYFNSVKRFD
   361  PVKKTWHQVA PMHSRRCYVS VTVLGNFIYA MGGFDGYVRL NTAERYEPET NQWTLIAPMH
   421  EQRSDASATT LYGKVYICGG FNGNECLFTA EVYNTESNQW TVIAPMRSRR SGIGVIAYGE
   481  HVYAVGGFDG ANRLRSAEAY SPVANTWRTI PTMFNPRSNF GIEVVDDLLF VVGGFNGFTT
   541  TFNVECYDEK TDEWYDAHDM SIYRSALSCC VVPGLANVEE YAARRDNFPG LALRDEVKYS
   601  ASTSTLPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • testis: 55 nTPM
  • epididymis: 1.4 nTPM
  • blood vessel: 0.9 nTPM
  • colon: 0.8 nTPM
  • seminal vesicle: 0.8 nTPM
  • smooth muscle: 0.7 nTPM

Single-cell type

  • late spermatids: 901 nCPM
  • early spermatids: 359 nCPM
  • late primary spermatocytes: 224 nCPM
  • cardiomyocytes: 67 nCPM
  • epicardial cells: 34 nCPM
  • myonuclei: 16 nCPM

Immune cell

  • MAIT T-cell: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 1.6 nTPM
  • cerebellum: 1.5 nTPM
  • hypothalamus: 1.3 nTPM
  • hippocampal formation: 1.2 nTPM
  • basal ganglia: 1.1 nTPM
  • white matter: 1.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KLHL10.

Disease | AllUniProt

Conditions KLHL10 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 80 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Spermatogenic failure 11

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.98
gnomAD missense Z
2.72
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL10 as an antibody target. Whether an autoantibody or antibody against KLHL10 could matter depends on whether native KLHL10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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