Seroatlas · Human Serome Atlas

KLHL9

Kelch-like protein 9

Also known as: FLJ13568, KIAA1354, KLHL9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2J3
Gene: KLHL9
Ensembl: ENSG00000198642
Chromosome: 9
Canonical length: 617 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the kelch repeat-containing family, and contains an N-terminal BTB/POZ domain, a BACK domain and six C-terminal kelch repeats. The encoded protein is a component of a complex with cullin 3-based E3 ligase, which plays a role in mitosis. This protein complex is a cell cycle regulator, and functions in the organization and integrity of the spindle midzone in anaphase and the completion of cytokinesis. The complex is required for the removal of the chromosomal passenger protein aurora B from mitotic chromosomes. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

617 residues, UniProt reviewed canonical sequence.

>Q9P2J3|KLHL9
     1  MKVSLGNGEM GVSAHLQPCK AGTTRFFTSN THSSVVLQGF DQLRIEGLLC DVTLVPGDGD
    61  EIFPVHRAMM ASASDYFKAM FTGGMKEQDL MCIKLHGVNK VGLKKIIDFI YTAKLSLNMD
   121  NLQDTLEAAS FLQILPVLDF CKVFLISGVS LDNCVEVGRI ANTYNLIEVD KYVNNFILKN
   181  FPALLSTGEF LKLPFERLAF VLSSNSLKHC TELELFKAAC RWLRLEDPRM DYAAKLMKNI
   241  RFPLMTPQDL INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDSTHL
   301  VTLGGVLRQQ LVVSKELRMY DERAQEWRSL APMDAPRYQH GIAVIGNFLY VVGGQSNYDT
   361  KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGH LYAVGGRSAA GELATVECYN
   421  PRMNEWSYVA KMSEPHYGHA GTVYGGLMYI SGGITHDTFQ NELMCFDPDT DKWMQKAPMT
   481  TVRGLHCMCT VGDKLYVIGG NHFRGTSDYD DVLSCEYYSP TLDQWTPIAA MLRGQSDVGV
   541  AVFENKIYVV GGYSWNNRCM VEIVQKYDPE KDEWHKVFDL PESLGGIRAC TLTVFPPEEN
   601  PGSPSRESPL SAPSDHS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

ovary: 18 nTPM
retina: 16 nTPM
placenta: 16 nTPM
breast: 16 nTPM
thyroid gland: 15 nTPM
prostate: 15 nTPM

Single-cell type

hepatic stellate cells: 65 nCPM
parietal cells: 58 nCPM
retinal pigment epithelial cells: 55 nCPM
neutrophil progenitors: 44 nCPM
prostatic glandular cells: 39 nCPM
pituicytes/fscs: 38 nCPM

Immune cell

eosinophil: 17 nTPM
basophil: 8.4 nTPM
non-classical monocyte: 7.2 nTPM
naive CD4 T-cell: 7.1 nTPM
intermediate monocyte: 6.8 nTPM
NK-cell: 6.2 nTPM

Brain region

white matter: 27 nTPM
cerebellum: 23 nTPM
hypothalamus: 22 nTPM
spinal cord: 21 nTPM
choroid plexus: 20 nTPM
medulla oblongata: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.82
gnomAD missense Z: 1.87
DepMap mean gene effect: 0.17
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cullin family protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL9 as an antibody target. Whether an autoantibody or antibody against KLHL9 could matter depends on whether native KLHL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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