ZBTB7B
Zinc finger and BTB domain-containing protein 7B
Also known as: c-Krox, hcKrox, ZBT7B_HUMAN, ZBTB15, ZFP67, ZNF857B
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O15156
- Gene
- ZBTB7B
- Ensembl
- ENSG00000160685
- Chromosome
- 1
- Canonical length
- 539 aa
- Protein class
- Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Canonical amino-acid sequenceUniProt
539 residues, UniProt reviewed canonical sequence.
>O15156|ZBTB7B
1 MGSPEDDLIG IPFPDHSSEL LSCLNEQRQL GHLCDLTIRT QGLEYRTHRA VLAACSHYFK
61 KLFTEGGGGA VMGAGGSGTA TGGAGAGVCE LDFVGPEALG ALLEFAYTAT LTTSSANMPA
121 VLQAARLLEI PCVIAACMEI LQGSGLEAPS PDEDDCERAR QYLEAFATAT ASGVPNGEDS
181 PPQVPLPPPP PPPPRPVARR SRKPRKAFLQ TKGARANHLV PEVPTVPAHP LTYEEEEVAG
241 RVGSSGGSGP GDSYSPPTGT ASPPEGPQSY EPYEGEEEEE ELVYPPAYGL AQGGGPPLSP
301 EELGSDEDAI DPDLMAYLSS LHQDNLAPGL DSQDKLVRKR RSQMPQECPV CHKIIHGAGK
361 LPRHMRTHTG EKPFACEVCG VRFTRNDKLK IHMRKHTGER PYSCPHCPAR FLHSYDLKNH
421 MHLHTGDRPY ECHLCHKAFA KEDHLQRHLK GQNCLEVRTR RRRKDDAPPH YPPPSTAAAS
481 PAGLDLSNGH LDTFRLSLAR FWEQSAPTGP PVSTPGPPDD DEEEGAPTTP QAEGAMESSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZBTB7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 107 nTPM
Expression across tissuesHPA
Tissue
- skin: 107 nTPM
- esophagus: 91 nTPM
- small intestine: 68 nTPM
- duodenum: 61 nTPM
- colon: 52 nTPM
- liver: 47 nTPM
Single-cell type
- enterocytes: 172 nCPM
- esophageal apical cells: 152 nCPM
- colonocytes: 110 nCPM
- esophageal suprabasal cells: 105 nCPM
- breast lactating cells: 87 nCPM
- neutrophils: 78 nCPM
Immune cell
- total PBMC: 2.6 nTPM
- neutrophil: 2.4 nTPM
- classical monocyte: 1.5 nTPM
- intermediate monocyte: 1.5 nTPM
- eosinophil: 1.4 nTPM
- non-classical monocyte: 1.3 nTPM
Brain region
- medulla oblongata: 35 nTPM
- thalamus: 34 nTPM
- white matter: 33 nTPM
- midbrain: 33 nTPM
- pons: 31 nTPM
- spinal cord: 30 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.52
- gnomAD pLI
- 0.34
- gnomAD missense Z
- 2.61
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- adaptive thermogenesis
- ectoderm development
- lactation
- negative regulation of CD8-positive, alpha-beta T cell differentiation
- negative regulation of gene expression
- negative regulation of T-helper 17 cell differentiation
- negative regulation of transcription by RNA polymerase II
- NK T cell differentiation
- positive regulation of brown fat cell differentiation
- positive regulation of CD4-positive, alpha-beta T cell differentiation
- positive regulation of cold-induced thermogenesis
- positive regulation of gene expression
- positive regulation of insulin receptor signaling pathway
- positive regulation of interleukin-17 production
- positive regulation of SREBP signaling pathway
- regulation of transcription by RNA polymerase II
- response to insulin
- transcription by RNA polymerase II
- negative regulation of NK T cell proliferation
Molecular functions
- DNA-binding transcription activator activity, RNA polymerase II-specific
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription repressor activity
- histone deacetylase binding
- protein homodimerization activity
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZBTB7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZBTB7B as an antibody target. Whether an autoantibody or antibody against ZBTB7B could matter depends on whether native ZBTB7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZBTB7B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZBTB7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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