Seroatlas · Human Serome Atlas

ZBTB45

Zinc finger and BTB domain-containing protein 45

Also known as: FLJ14486, ZBT45_HUMAN, ZNF499

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K62
Gene: ZBTB45
Ensembl: ENSG00000119574
Chromosome: 19
Canonical length: 511 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nuclear bodies,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

511 residues, UniProt reviewed canonical sequence.

>Q96K62|ZBTB45
     1  MAAAEAVHHI HLQNFSRSLL ETLNGQRLGG HFCDVTVRIR EASLRAHRCV LAAGSPFFQD
    61  KLLLGHSEIR VPPVVPAQTV RQLVEFLYSG SLVVAQGEAL QVLTAASVLR IQTVIDECTQ
   121  IIARARAPGT SAPTPLPTPV PPPLAPAQLR HRLRHLLAAR PPGHPGAAHS RKQRQPARLQ
   181  LPAPPTPAKA EGPDADPSLS AAPDDRGDED DEESDDETDG EDGEGGGPGE GQAPPSFPDC
   241  AAGFLTAAAD SACEEPPAPT GLADYSGAGR DFLRGAGSAE DVFPDSYVST WHDEDGAVPE
   301  GCPTETPVQP DCILSGSRPP GVKTPGPPVA LFPFHLGAPG PPAPPPSAPS GPAPAPPPAF
   361  YPTLQPEAAP STQLGEVPAP SAAPTTAPSG TPARTPGAEP PTYECSHCRK TFSSRKNYTK
   421  HMFIHSGEKP HQCAVCWRSF SLRDYLLKHM VTHTGVRAFQ CAVCAKRFTQ KSSLNVHMRT
   481  HRPERAPCPA CGKVFSHRAL LERHLAAHPA P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 16 nTPM
skin: 13 nTPM
endometrium: 12 nTPM
blood vessel: 12 nTPM
cerebellum: 11 nTPM
hippocampal formation: 11 nTPM

Single-cell type

early primary spermatocytes: 33 nCPM
hepatic stellate cells: 19 nCPM
cardiomyocytes: 19 nCPM
megakaryocytes: 19 nCPM
oocytes: 14 nCPM
esophageal suprabasal cells: 12 nCPM

Immune cell

eosinophil: 10 nTPM
non-classical monocyte: 9.2 nTPM
intermediate monocyte: 7.6 nTPM
MAIT T-cell: 6.8 nTPM
plasmacytoid DC: 6.4 nTPM
basophil: 5.8 nTPM

Brain region

cerebral cortex: 33 nTPM
pons: 28 nTPM
medulla oblongata: 25 nTPM
white matter: 24 nTPM
hippocampal formation: 24 nTPM
midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB45 as an antibody target. Whether an autoantibody or antibody against ZBTB45 could matter depends on whether native ZBTB45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB45 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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