Seroatlas · Human Serome Atlas

KBTBD3

Kelch repeat and BTB domain-containing protein 3

Also known as: BKLHD3, KBTB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NAB2
Gene
KBTBD3
Ensembl
ENSG00000182359
Chromosome
11
Canonical length
612 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nucleus. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

612 residues, UniProt reviewed canonical sequence.

>Q8NAB2|KBTBD3
     1  MELAMDNSYA FNQRSTCNGI PSEKKNNFLV SEDHGQKILS VLQNFREQNV FYDFKIIMKD
    61  EIIPCHRCVL AACSDFFRAM FEVNMKERDD GSVTITNLSS KAVKAFLDYA YTGKTKITDD
   121  NVEMFFQLSS FLQVSFLSKA CSDFLIKSIN LVNCLQLLSI SDSYGSTSLF DHALHFVQHH
   181  FSLLFKSSDF LEMNFGVLQK CLESDELNVP EEEMVLKVVL SWTKHNLESR QKYLPHLIEK
   241  VRLHQLSEET LQDCLFNEES LLKSTNCFDI IMDAIKCVQG SGGLFPDARP STTEKYIFIH
   301  KTEENGENQY TFCYNIKSDS WKILPQSHLI DLPGSSLSSY GEKIFLTGGC KGKCCRTVRL
   361  HIAESYHDAT DQTWCYCPVK NDFFLVSTMK TPRTMHTSVM ALDRLFVIGG KTRGSRDIKS
   421  LLDVESYNPL SKEWISVSPL PRGIYYPEAS TCQNVIYVLG SEVEITDAFN PSLDCFFKYN
   481  ATTDQWSELV AEFGQFFHAT LIKAVPVNCT LYICDLSTYK VYSFCPDTCV WKGEGSFECA
   541  GFNAGAIGIE DKIYILGGDY APDEITDEVQ VYHSNRSEWE EVSPMPRALT EFYCQVIQFN
   601  KYRDPWFSNL CA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KBTBD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
9.6 nTPM

Expression across tissuesHPA

Tissue

  • retina: 9.6 nTPM
  • choroid plexus: 5.8 nTPM
  • spinal cord: 5.2 nTPM
  • epididymis: 4.1 nTPM
  • kidney: 3.9 nTPM
  • cerebellum: 3.7 nTPM

Single-cell type

  • early spermatids: 115 nCPM
  • late primary spermatocytes: 90 nCPM
  • epididymal principal cells: 49 nCPM
  • oligodendrocytes: 48 nCPM
  • gastric chief cells: 42 nCPM
  • corticotrophs: 40 nCPM

Immune cell

  • basophil: 31 nTPM
  • eosinophil: 19 nTPM
  • T-reg: 16 nTPM
  • NK-cell: 15 nTPM
  • memory CD4 T-cell: 14 nTPM
  • memory B-cell: 13 nTPM

Brain region

  • cerebellum: 22 nTPM
  • white matter: 20 nTPM
  • pons: 16 nTPM
  • cerebral cortex: 15 nTPM
  • thalamus: 14 nTPM
  • medulla oblongata: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.88
gnomAD pLI
0
gnomAD missense Z
0.84
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KBTBD3 as an antibody target. Whether an autoantibody or antibody against KBTBD3 could matter depends on whether native KBTBD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KBTBD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KBTBD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KBTBD3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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