Seroatlas · Human Serome Atlas

KBTBD7

Kelch repeat and BTB domain-containing protein 7

Also known as: DKFZP434E2318, KBTB7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8WVZ9
Gene
KBTBD7
Ensembl
ENSG00000120696
Chromosome
13
Canonical length
684 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

684 residues, UniProt reviewed canonical sequence.

>Q8WVZ9|KBTBD7
     1  MQSREDVPRS RRLASPRGGR RPKRISKPSV SAFFTGPEEL KDTAHSAALL AQLKSFYDAR
    61  LLCDVTIEVV TPGSGPGTGR LFSCNRNVLA AACPYFKSMF TGGMYESQQA SVTMHDVDAE
   121  SFEVLVDYCY TGRVSLSEAN VQRLYAASDM LQLEYVREAC ASFLARRLDL TNCTAILKFA
   181  DAFDHHKLRS QAQSYIAHNF KQLSRMGSIR EETLADLTLA QLLAVLRLDS LDIESERTVC
   241  HVAVQWLEAA AKERGPSAAE VFKCVRWMHF TEEDQDYLEG LLTKPIVKKY CLDVIEGALQ
   301  MRYGDLLYKS LVPVPNSSSS SSSSNSLVSA AENPPQRLGM CAKEMVIFFG HPRDPFLCYD
   361  PYSGDIYTMP SPLTSFAHTK TVTSSAVCVS PDHDIYLAAQ PRKDLWVYKP AQNSWQQLAD
   421  RLLCREGMDV AYLNGYIYIL GGRDPITGVK LKEVECYSVQ RNQWALVAPV PHSFYSFELI
   481  VVQNYLYAVN SKRMLCYDPS HNMWLNCASL KRSDFQEACV FNDEIYCICD IPVMKVYNPA
   541  RGEWRRISNI PLDSETHNYQ IVNHDQKLLL ITSTTPQWKK NRVTVYEYDT REDQWINIGT
   601  MLGLLQFDSG FICLCARVYP SCLEPGQSFI TEEDDARSES STEWDLDGFS ELDSESGSSS
   661  SFSDDEVWVQ VAPQRNAQDQ QGSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KBTBD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
6.5 nTPM

Expression across tissuesHPA

Tissue

  • liver: 6.5 nTPM
  • cerebral cortex: 6.1 nTPM
  • cerebellum: 5.9 nTPM
  • thyroid gland: 5.9 nTPM
  • parathyroid gland: 5.8 nTPM
  • retina: 5.6 nTPM

Single-cell type

  • epididymal basal cells: 187 nCPM
  • neutrophil progenitors: 153 nCPM
  • neutrophils: 133 nCPM
  • early spermatids: 71 nCPM
  • parietal cells: 35 nCPM
  • hepatocytes: 33 nCPM

Immune cell

  • neutrophil: 14 nTPM
  • eosinophil: 12 nTPM
  • intermediate monocyte: 5.1 nTPM
  • classical monocyte: 5 nTPM
  • naive CD4 T-cell: 5 nTPM
  • naive CD8 T-cell: 4.5 nTPM

Brain region

  • cerebellum: 13 nTPM
  • white matter: 12 nTPM
  • choroid plexus: 10 nTPM
  • basal ganglia: 9.9 nTPM
  • spinal cord: 9.9 nTPM
  • cerebral cortex: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.92
gnomAD pLI
0
gnomAD missense Z
1.66
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KBTBD7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KBTBD7 as an antibody target. Whether an autoantibody or antibody against KBTBD7 could matter depends on whether native KBTBD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KBTBD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KBTBD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KBTBD7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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