Seroatlas · Human Serome Atlas

ZBTB47

Zinc finger and BTB domain-containing protein 47

Also known as: DKFZp434N0615, KIAA1190, ZBT47_HUMAN, ZNF651

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UFB7
Gene: ZBTB47
Ensembl: ENSG00000114853
Chromosome: 3
Canonical length: 747 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>Q9UFB7|ZBTB47
     1  MGRLNEQRLF QPDLCDVDLV LVPQRSVFPA HKGVLAAYSQ FFHSLFTQNK QLQRVELSLE
    61  ALAPGGLQQI LNFIYTSKLL VNAANVHEVL SAASLLQMAD IAASCQELLD ARSLGPPGPG
   121  TVALAQPAAS CTPAAPPYYC DIKQEADTPG LPKIYAREGP DPYSVRVEDG AGTAGGTVPA
   181  TIGPAQPFFK EEKEGGVEEA GGPPASLCKL EGGEELEEEL GGSGTYSRRE QSQIIVEVNL
   241  NNQTLHVSTG PEGKPGAGPS PATVVLGRED GLQRHSDEEE EDDEEEEEEE EEEEGGGSGR
   301  EEEEEEEGGS QGEEEEEEED GHSEQEEEEE EEEEEGPSEQ DQESSEEEEG EEGEAGGKQG
   361  PRGSRSSRAD PPPHSHMATR SRENARRRGT PEPEEAGRRG GKRPKPPPGV ASASARGPPA
   421  TDGLGAKVKL EEKQHHPCQK CPRVFNNRWY LEKHMNVTHS RMQICDQCGK RFLLESELLL
   481  HRQTDCERNI QCVTCGKAFK KLWSLHEHNK IVHGYAEKKF SCEICEKKFY TMAHVRKHMV
   541  AHTKDMPFTC ETCGKSFKRS MSLKVHSLQH SGEKPFRCEN CNERFQYKYQ LRSHMSIHIG
   601  HKQFMCQWCG KDFNMKQYFD EHMKTHTGEK PYICEICGKS FTSRPNMKRH RRTHTGEKPY
   661  PCDVCGQRFR FSNMLKAHKE KCFRVSHTLA GDGVPAAPGL PPTQPQAHAL PLLPGLPQTL
   721  PPPPHLPPPP PLFPTTASPG GRMNANN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB47 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 99 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 99 nTPM
heart muscle: 66 nTPM
tongue: 59 nTPM
amygdala: 58 nTPM
basal ganglia: 58 nTPM
spinal cord: 58 nTPM

Single-cell type

cardiomyocytes: 52 nCPM
thymic myoid cells: 31 nCPM
astrocytes: 29 nCPM
vascular smooth muscle cells: 23 nCPM
early spermatids: 22 nCPM
adrenal medulla cells: 21 nCPM

Immune cell

neutrophil: 0.6 nTPM
classical monocyte: 0.4 nTPM
intermediate monocyte: 0.4 nTPM
myeloid DC: 0.2 nTPM
non-classical monocyte: 0.2 nTPM
total PBMC: 0.1 nTPM

Brain region

white matter: 120 nTPM
amygdala: 108 nTPM
medulla oblongata: 101 nTPM
thalamus: 99 nTPM
basal ganglia: 96 nTPM
cerebral cortex: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.12
gnomAD pLI: 1
gnomAD missense Z: 2.45
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB47 as an antibody target. Whether an autoantibody or antibody against ZBTB47 could matter depends on whether native ZBTB47 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB47 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB47 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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