Seroatlas · Human Serome Atlas

SANBR

SANT and BTB domain regulator of class switch recombination

Also known as: KIAA1841, SANBR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NSI8
Gene
SANBR
Ensembl
ENSG00000162929
Chromosome
2
Canonical length
718 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in isotype switching. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

718 residues, UniProt reviewed canonical sequence.

>Q6NSI8|SANBR
     1  MSRGYSENNN FLNNNNQMVL DMILYPLIGI PQTINWETIA RLVPGLTPKE CAKRFDELKS
    61  SGSSPVDNQY NSLMAAGESP VETLATYIKS SLLDIHGEFQ ETPVGHDAVS KTGRHSIAST
   121  RNCSSESENC TTHNGGEMTE ESEGPNMVIH VCDEAKNLKE DFTCPRDLLI SEMKYFAEYL
   181  SMDAQRWEEV DISVHCDVHI FNWLIKYIKR NTKENKDCEM PTLEPGNVIS ILISSEFLKM
   241  DSLVEQCIQY CHKNMNAIVA TPCNMNCINA NLLTRIADLF SHNEVDDLKD KKDKFKSKLF
   301  CKKIERLFDP EYLNPDSRSN AATLYRCCLC KKLLTKETER RIPCIPGKIN VDRRGNIVYI
   361  HIRDKTWDVH EYLNSLFEEL KSWRDVYWRL WGTINWLTCS RCYQAFLCIE FSHCQYHSET
   421  VVYPTAASSL NTVGTGIYPC CNQKVLRFDP TQLTKGCKVR DHMVTLRDQG EGGDLPSCPT
   481  ARMLDDLHKY RDVIVVPFSK DTVSDVGVGL CDEKGIECDV LLEPNTPWGP KTGELNAFLS
   541  LKNWTLQLKQ QSLFSEEEEY TTGSEVTEDE VGDEEEVSKK QRKKEKPKKF TRQPKKQVSS
   601  PCAQRKEKAL EKSASRDVSP FVMSMQKNKW DATRSLRFNQ DAQREDDQRR MTEITGHLIK
   661  MRLGDLDRVK SKEAKEFAGG IYSRLEAQIK ASVPVSARQS SSEKNTRSKS RFGQGRPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SANBR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • retina: 10 nTPM
  • spinal cord: 6.7 nTPM
  • cerebellum: 6.2 nTPM
  • hypothalamus: 5.7 nTPM
  • hippocampal formation: 4.7 nTPM
  • cerebral cortex: 4.6 nTPM

Single-cell type

  • retinal ganglion cells: 228 nCPM
  • respiratory ciliated cells: 157 nCPM
  • ependymal cells: 135 nCPM
  • other brain neurons: 113 nCPM
  • brain excitatory neurons: 109 nCPM
  • cone photoreceptor cells: 99 nCPM

Immune cell

  • eosinophil: 1.8 nTPM
  • T-reg: 1.5 nTPM
  • neutrophil: 1.2 nTPM
  • non-classical monocyte: 1 nTPM
  • intermediate monocyte: 0.7 nTPM
  • classical monocyte: 0.5 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • white matter: 16 nTPM
  • pons: 15 nTPM
  • hypothalamus: 14 nTPM
  • medulla oblongata: 12 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of SANBR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SANBR as an antibody target. Whether an autoantibody or antibody against SANBR could matter depends on whether native SANBR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SANBR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SANBR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SANBR. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...