Seroatlas · Human Serome Atlas

SHKBP1

SH3KBP1-binding protein 1

Also known as: PP203, Sb1, SHKB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBC3
Gene: SHKBP1
Ensembl: ENSG00000160410
Chromosome: 19
Canonical length: 707 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in positive regulation of epidermal growth factor receptor signaling pathway. Predicted to be located in lysosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

707 residues, UniProt reviewed canonical sequence.

>Q8TBC3|SHKBP1
     1  MAAAATAAEG VPSRGPPGEV IHLNVGGKRF STSRQTLTWI PDSFFSSLLS GRISTLKDET
    61  GAIFIDRDPT VFAPILNFLR TKELDPRGVH GSSLLHEAQF YGLTPLVRRL QLREELDRSS
   121  CGNVLFNGYL PPPVFPVKRR NRHSLVGPQQ LGGRPAPVRR SNTMPPNLGN AGLLGRMLDE
   181  KTPPSPSGQP EEPGMVRLVC GHHNWIAVAY TQFLVCYRLK EASGWQLVFS SPRLDWPIER
   241  LALTARVHGG ALGEHDKMVA AATGSEILLW ALQAEGGGSE IGVFHLGVPV EALFFVGNQL
   301  IATSHTGRIG VWNAVTKHWQ VQEVQPITSY DAAGSFLLLG CNNGSIYYVD VQKFPLRMKD
   361  NDLLVSELYR DPAEDGVTAL SVYLTPKTSD SGNWIEIAYG TSSGGVRVIV QHPETVGSGP
   421  QLFQTFTVHR SPVTKIMLSE KHLISVCADN NHVRTWSVTR FRGMISTQPG STPLASFKIL
   481  ALESADGHGG CSAGNDIGPY GERDDQQVFI QKVVPSASQL FVRLSSTGQR VCSVRSVDGS
   541  PTTAFTVLEC EGSRRLGSRP RRYLLTGQAN GSLAMWDLTT AMDGLGQAPA GGLTEQELME
   601  QLEHCELAPP APSAPSWGCL PSPSPRISLT SLHSASSNTS LSGHRGSPSP PQAEARRRGG
   661  GSFVERCQEL VRSGPDLRRP PTPAPWPSSG LGTPLTPPKM KLNETSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SHKBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

spleen: 124 nTPM
bone marrow: 63 nTPM
lung: 52 nTPM
esophagus: 46 nTPM
small intestine: 44 nTPM
kidney: 41 nTPM

Single-cell type

neutrophils: 511 nCPM
monocytes: 106 nCPM
monocyte progenitors: 92 nCPM
hofbauer cells: 84 nCPM
neutrophil progenitors: 80 nCPM
extravillous trophoblasts: 75 nCPM

Immune cell

neutrophil: 456 nTPM
non-classical monocyte: 248 nTPM
basophil: 225 nTPM
classical monocyte: 218 nTPM
eosinophil: 217 nTPM
total PBMC: 213 nTPM

Brain region

medulla oblongata: 26 nTPM
white matter: 26 nTPM
thalamus: 26 nTPM
cerebral cortex: 25 nTPM
pons: 21 nTPM
midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.98
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

lysosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SHKBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SHKBP1 as an antibody target. Whether an autoantibody or antibody against SHKBP1 could matter depends on whether native SHKBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SHKBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SHKBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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