Seroatlas · Human Serome Atlas

BCL6

B-cell lymphoma 6 protein

Also known as: BCL5, BCL6_HUMAN, BCL6A, LAZ3, ZBTB27, ZNF51

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P41182
Gene: BCL6
Ensembl: ENSG00000113916
Chromosome: 3
Canonical length: 706 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Canonical amino-acid sequenceUniProt

706 residues, UniProt reviewed canonical sequence.

>P41182|BCL6
     1  MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI
    61  FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT
   121  CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF
   181  APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG
   241  EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG LKPAAPSARN APYFPCDKAS
   301  KEEERPSSED EIALHFEPPN APLNRKGLVS PQSPQKSDCQ PNSPTESCSS KNACILQASG
   361  SPPAKSPTDP KACNWKKYKF IVLNSLNQNA KPEGPEQAEL GRLSPRAYTA PPACQPPMEP
   421  ENLDLQSPTK LSASGEDSTI PQASRLNNIV NRSMTGSPRS SSESHSPLYM HPPKCTSCGS
   481  QSPQHAEMCL HTAGPTFPEE MGETQSEYSD SSCENGAFFC NECDCRFSEE ASLKRHTLQT
   541  HSDKPYKCDR CQASFRYKGN LASHKTVHTG EKPYRCNICG AQFNRPANLK THTRIHSGEK
   601  PYKCETCGAR FVQVAHLRAH VLIHTGEKPY PCEICGTRFR HLQTLKSHLR IHTGEKPYHC
   661  EKCNLHFRHK SQLRLHLRQK HGAITNTKVQ YRVSATDLPP ELPKAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BCL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 528 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 528 nTPM
skin: 171 nTPM
adipose tissue: 153 nTPM
blood vessel: 143 nTPM
breast: 140 nTPM
spleen: 120 nTPM

Single-cell type

neutrophils: 2,732 nCPM
myonuclei: 503 nCPM
neutrophil progenitors: 335 nCPM
adipocytes: 287 nCPM
thymic myoid cells: 264 nCPM
smooth muscle cells: 256 nCPM

Immune cell

neutrophil: 270 nTPM
non-classical monocyte: 77 nTPM
intermediate monocyte: 37 nTPM
classical monocyte: 33 nTPM
total PBMC: 31 nTPM
myeloid DC: 25 nTPM

Brain region

medulla oblongata: 188 nTPM
cerebellum: 146 nTPM
pons: 117 nTPM
thalamus: 116 nTPM
hypothalamus: 113 nTPM
white matter: 100 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BCL6.

Disease | ImmuneIEDB

Conditions an epitope on BCL6 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell
sleep disorder B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.96
gnomAD missense Z: 2.25
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BCL6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BCL6 as an antibody target. Whether an autoantibody or antibody against BCL6 could matter depends on whether native BCL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BCL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BCL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...