Seroatlas · Human Serome Atlas

KCTD4

BTB/POZ domain-containing protein KCTD4

Also known as: bA321C24.3, KCTD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVF5
Gene: KCTD4
Ensembl: ENSG00000180332
Chromosome: 13
Canonical length: 259 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Centriolar satellite

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in protein homooligomerization. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q8WVF5|KCTD4
     1  MERKINRREK EKEYEGKHNS LEDTDQGKNC KSTLMTLNVG GYLYITQKQT LTKYPDTFLE
    61  GIVNGKILCP FDADGHYFID RDGLLFRHVL NFLRNGELLL PEGFRENQLL AQEAEFFQLK
   121  GLAEEVKSRW EKEQLTPRET TFLEITDNHD RSQGLRIFCN APDFISKIKS RIVLVSKSRL
   181  DGFPEEFSIS SNIIQFKYFI KSENGTRLVL KEDNTFVCTL ETLKFEAIMM ALKCGFRLLT
   241  SLDCSKGSIV HSDALHFIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 45 nTPM
amygdala: 26 nTPM
hippocampal formation: 15 nTPM
cerebral cortex: 8.7 nTPM
hypothalamus: 6.9 nTPM
spinal cord: 5 nTPM

Single-cell type

retinal pigment epithelial cells: 73 nCPM
oligodendrocytes: 15 nCPM
epicardial cells: 11 nCPM
oligodendrocyte progenitor cells: 11 nCPM
cardiomyocytes: 8.9 nCPM
brain inhibitory neurons: 8.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 33 nTPM
amygdala: 25 nTPM
cerebral cortex: 19 nTPM
hippocampal formation: 18 nTPM
white matter: 13 nTPM
hypothalamus: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.78
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein homooligomerization

Molecular functions

identical protein binding

Protein domainsUniProt · Pfam · InterPro

BTB/POZ domain
Potassium channel tetramerisation-type BTB domain
SKP1/BTB/POZ domain superfamily
BTB/POZ domain
BTB/POZ domain-containing protein KCTD4, C-terminal
BTB/POZ domain-containing protein KCTD4 C-terminus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD4 as an antibody target. Whether an autoantibody or antibody against KCTD4 could matter depends on whether native KCTD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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