Seroatlas · Human Serome Atlas

ZBTB44

Zinc finger and BTB domain-containing protein 44

Also known as: BTBD15, HSPC063, ZBT44_HUMAN, ZNF851

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCP5
Gene: ZBTB44
Ensembl: ENSG00000196323
Chromosome: 11
Canonical length: 570 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

570 residues, UniProt reviewed canonical sequence.

>Q8NCP5|ZBTB44
     1  MGVKTFTHSS SSHSQEMLGK LNMLRNDGHF CDITIRVQDK IFRAHKVVLA ACSDFFRTKL
    61  VGQAEDENKN VLDLHHVTVT GFIPLLEYAY TATLSINTEN IIDVLAAASY MQMFSVASTC
   121  SEFMKSSILW NTPNSQPEKG LDAGQENNSN CNFTSRDGSI SPVSSECSVV ERTIPVCRES
   181  RRKRKSYIVM SPESPVKCGT QTSSPQVLNS SASYSENRNQ PVDSSLAFPW TFPFGIDRRI
   241  QPEKVKQAEN TRTLELPGPS ETGRRMADYV TCESTKTTLP LGTEEDVRVK VERLSDEEVH
   301  EEVSQPVSAS QSSLSDQQTV PGSEQVQEDL LISPQSSSIG SVDEGVSEGL PTLQSTSSTN
   361  APPDDDDRLE NVQYPYQLYI APSTSSTERP SPNGPDRPFQ CPTCGVRFTR IQNLKQHMLI
   421  HSGIKPFQCD RCGKKFTRAY SLKMHRLKHE GKRCFRCQIC SATFTSFGEY KHHMRVSRHI
   481  IRKPRIYECK TCGAMFTNSG NLIVHLRSLN HEASELANYF QSSDFLVPDY LNQEQEETLV
   541  QYDLGEHGFE SNSSVQMPVI SQYHSKGKEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

testis: 34 nTPM
skeletal muscle: 34 nTPM
tongue: 29 nTPM
kidney: 24 nTPM
thymus: 24 nTPM
epididymis: 17 nTPM

Single-cell type

endometrial luminal cells: 227 nCPM
myonuclei: 200 nCPM
sertoli cells: 196 nCPM
endometrial secretory cells: 192 nCPM
endometrial glandular cells: 161 nCPM
oligodendrocytes: 155 nCPM

Immune cell

gdT-cell: 2 nTPM
neutrophil: 2 nTPM
plasmacytoid DC: 1.6 nTPM
T-reg: 1.6 nTPM
NK-cell: 1.5 nTPM
MAIT T-cell: 1.3 nTPM

Brain region

cerebellum: 60 nTPM
basal ganglia: 49 nTPM
white matter: 49 nTPM
thalamus: 49 nTPM
midbrain: 46 nTPM
amygdala: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.14
gnomAD pLI: 1
gnomAD missense Z: 1.87
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB44 as an antibody target. Whether an autoantibody or antibody against ZBTB44 could matter depends on whether native ZBTB44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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