Seroatlas · Human Serome Atlas

KCNG3

Voltage-gated potassium channel regulatory subunit KCNG3

Also known as: KCNG3_HUMAN, Kv6.3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TAE7
Gene
KCNG3
Ensembl
ENSG00000171126
Chromosome
2
Canonical length
436 aa
Protein class
Predicted membrane proteins, Voltage-gated ion channels
Subcellular location
Cytoplasmic bodies
Quaternary structure
Homomultimer

OverviewNCBI Gene

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q8TAE7|KCNG3
     1  MTFGRSGAAS VVLNVGGARY SLSRELLKDF PLRRVSRLHG CRSERDVLEV CDDYDRERNE
    61  YFFDRHSEAF GFILLYVRGH GKLRFAPRMC ELSFYNEMIY WGLEGAHLEY CCQRRLDDRM
   121  SDTYTFYSAD EPGVLGRDEA RPGGAEAAPS RRWLERMRRT FEEPTSSLAA QILASVSVVF
   181  VIVSMVVLCA STLPDWRNAA ADNRSLDDRS RYSAGPGREP SGIIEAICIG WFTAECIVRF
   241  IVSKNKCEFV KRPLNIIDLL AITPYYISVL MTVFTGENSQ LQRAGVTLRV LRMMRIFWVI
   301  KLARHFIGLQ TLGLTLKRCY REMVMLLVFI CVAMAIFSAL SQLLEHGLDL ETSNKDFTSI
   361  PAACWWVIIS MTTVGYGDMY PITVPGRILG GVCVVSGIVL LALPITFIYH SFVQCYHELK
   421  FRSARYSRSL STEFLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
1 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 1 nTPM
  • adrenal gland: 0.8 nTPM
  • cerebral cortex: 0.7 nTPM
  • thymus: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • hippocampal formation: 0.5 nTPM

Single-cell type

  • endometrial luminal cells: 170 nCPM
  • endometrial glandular cells: 139 nCPM
  • endometrial ciliated cells: 81 nCPM
  • corticotrophs: 70 nCPM
  • renal collecting duct intercalated cells: 57 nCPM
  • thyrotrophs: 40 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hippocampal formation: 17 nTPM
  • cerebral cortex: 13 nTPM
  • basal ganglia: 9.7 nTPM
  • pons: 8.9 nTPM
  • amygdala: 8.5 nTPM
  • midbrain: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.27
gnomAD missense Z
2.32
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNG3 as an antibody target. Whether an autoantibody or antibody against KCNG3 could matter depends on whether native KCNG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNG3 is annotated at the cell surface, where native KCNG3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNG3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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