Seroatlas · Human Serome Atlas

KLHL33

Kelch-like protein 33

Also known as: KLH33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCF5
Gene: KLHL33
Ensembl: ENSG00000185271
Chromosome: 14
Canonical length: 533 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for KLHL33 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

533 residues, UniProt reviewed canonical sequence.

>A6NCF5|KLHL33
     1  MLLSGMRESQ GTEVSLRTIS TQDLRLLVSF AYSGVVRARW PGLLRAAQAA LQYQSSSCLD
    61  LCQKGLARGL SPARCLALFP MAEAPGLERL WSKARHYLLT HLPAVALCPA FPSLPAACLA
   121  ELLDSDELHV QEEFEAFVAA RCWLAANPET QESEAKALLR CVRFGRMSTR ELRRVRAAGL
   181  LPPLTPDLLH QLMVEADVPG QERRREPDRA LVVIGGDGLR PDMALRQPSR AVWWARAFRC
   241  GVGLVRTVEW GQLPALPAPG RFRHGAASLA GSELYVCGGQ DFYSHSNTLA STLRWEPSQE
   301  DWEEMAPLSQ ARSLFSLVAL DGKLYALGGR HNDVALDSVE TYNPELNVWR PAPALPAPCF
   361  AHAAAILEGQ LYVSGGCGGT GQYLASLMHY DPKLEKPGTF LSPMGVPRAG HVMAALGGRL
   421  YVAGGLGETE DLLSFEAYEL RTDSWTHLAP LPSPHVGAAS AVLQGELLVL GGYSHRTYAL
   481  SHLIHAYCPG LGRWLCLGTL PRPRAEMPAC ILTLPAVQHI ALVPTPHQTK PAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 69 nTPM
tongue: 19 nTPM
endometrium: 1.3 nTPM
epididymis: 1 nTPM
ovary: 1 nTPM
seminal vesicle: 1 nTPM

Single-cell type

myonuclei: 72 nCPM
pdcs: 13 nCPM
thymic myoid cells: 11 nCPM
fibro-adipogenic progenitors: 7.8 nCPM
leydig cells: 6.5 nCPM
peritubular myoid cells: 5.7 nCPM

Immune cell

plasmacytoid DC: 5.8 nTPM
basophil: 0.2 nTPM
naive B-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebellum: 5.1 nTPM
midbrain: 3.5 nTPM
white matter: 3.5 nTPM
cerebral cortex: 3.3 nTPM
basal ganglia: 3.2 nTPM
hypothalamus: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Kelch repeat type 1
SKP1/BTB/POZ domain superfamily
BTB/Kelch-associated
Kelch-type beta-propeller
BTB-kelch protein
Kelch motif
BTB And C-terminal Kelch
KLHDC2/KLHL20/DRC7 Kelch-repeats domain
Kelch-like protein 33, BACK domain
Kelch-like protein 33-like, BTB/POZ domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL33 as an antibody target. Whether an autoantibody or antibody against KLHL33 could matter depends on whether native KLHL33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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