Seroatlas · Human Serome Atlas

ZBTB14

Zinc finger and BTB domain-containing protein 14

Also known as: ZBT14_HUMAN, ZFP161, ZNF478

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43829
Gene
ZBTB14
Ensembl
ENSG00000198081
Chromosome
18
Canonical length
449 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Nucleoplasm,Nucleoli,Cytosol

OverviewNCBI Gene

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in negative regulation of DNA-templated transcription. Located in aggresome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>O43829|ZBTB14
     1  MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH RCVLAACSTY
    61  FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV KKEDVNLMMS SGQILGIRFL
   121  DKLCSQKRDV SSPDENNGQS KSKYCLKINR PIGDAADTQD DDVEEIGDQD DSPSDDTVEG
   181  TPPSQEDGKS PTTTLRVQEA ILKELGSEEV RKVNCYGQEV ESMETPESKD LGSQTPQALT
   241  FNDGMSEVKD EQTPGWTTAA SDMKFEYLLY GHHREQIACQ ACGKTFSDEG RLRKHEKLHT
   301  ADRPFVCEMC TKGFTTQAHL KEHLKIHTGY KPYSCEVCGK SFIRAPDLKK HERVHSNERP
   361  FACHMCDKAF KHKSHLKDHE RRHRGEKPFV CGSCTKAFAK ASDLKRHENN MHSERKQVTP
   421  SAIQSETEQL QAAAMAAEAE QQLETIACS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 23 nTPM
  • tonsil: 20 nTPM
  • thymus: 20 nTPM
  • epididymis: 16 nTPM
  • spleen: 15 nTPM
  • thyroid gland: 15 nTPM

Single-cell type

  • respiratory ionocytes: 20 nCPM
  • platelets: 20 nCPM
  • megakaryocytes: 19 nCPM
  • parietal cells: 18 nCPM
  • megakaryocyte progenitors: 14 nCPM
  • monocyte progenitors: 14 nCPM

Immune cell

  • eosinophil: 14 nTPM
  • naive CD4 T-cell: 12 nTPM
  • naive CD8 T-cell: 11 nTPM
  • memory CD4 T-cell: 11 nTPM
  • naive B-cell: 11 nTPM
  • memory CD8 T-cell: 10 nTPM

Brain region

  • cerebellum: 18 nTPM
  • white matter: 17 nTPM
  • basal ganglia: 16 nTPM
  • spinal cord: 16 nTPM
  • midbrain: 16 nTPM
  • medulla oblongata: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0.26
gnomAD missense Z
2.94
DepMap mean gene effect
0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB14 as an antibody target. Whether an autoantibody or antibody against ZBTB14 could matter depends on whether native ZBTB14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZBTB14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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