Seroatlas · Human Serome Atlas

LZTR1

Leucine-zipper-like transcriptional regulator 1

Also known as: BTBD29, LZTR-1, LZTR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N653
Gene
LZTR1
Ensembl
ENSG00000099949
Chromosome
22
Canonical length
840 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

840 residues, UniProt reviewed canonical sequence.

>Q8N653|LZTR1
     1  MAGPGSTGGQ IGAAALAGGA RSKVAPSVDF DHSCSDSVEY LTLNFGPFET VHRWRRLPPC
    61  DEFVGARRSK HTVVAYKDAI YVFGGDNGKT MLNDLLRFDV KDCSWCRAFT TGTPPAPRYH
   121  HSAVVYGSSM FVFGGYTGDI YSNSNLKNKN DLFEYKFATG QWTEWKIEGR LPVARSAHGA
   181  TVYSDKLWIF AGYDGNARLN DMWTIGLQDR ELTCWEEVAQ SGEIPPSCCN FPVAVCRDKM
   241  FVFSGQSGAK ITNNLFQFEF KDKTWTRIPT EHLLRGSPPP PQRRYGHTMV AFDRHLYVFG
   301  GAADNTLPNE LHCYDVDFQT WEVVQPSSDS EVGGAEVPER ACASEEVPTL TYEERVGFKK
   361  SRDVFGLDFG TTSAKQPTQP ASELPSGRLF HAAAVISDAM YIFGGTVDNN IRSGEMYRFQ
   421  FSCYPKCTLH EDYGRLWESR QFCDVEFVLG EKEECVQGHV AIVTARSRWL RRKITQARER
   481  LAQKLEQEAA PVPREAPGVA AGGARPPLLH VAIREAEARP FEVLMQFLYT DKIKYPRKGH
   541  VEDVLLIMDV YKLALSFQLC RLEQLCRQYI EASVDLQNVL VVCESAARLQ LSQLKEHCLN
   601  FVVKESHFNQ VIMMKEFERL SSPLIVEIVR RKQQPPPRTP LDQPVDIGTS LIQDMKAYLE
   661  GAGAEFCDIT LLLDGHPRPA HKAILAARSS YFEAMFRSFM PEDGQVNISI GEMVPSRQAF
   721  ESMLRYIYYG EVNMPPEDSL YLFAAPYYYG FYNNRLQAYC KQNLEMNVTV QNVLQILEAA
   781  DKTQALDMKR HCLHIIVHQF TKVSKLPTLR SLSQQLLLDI IDSLASHISD KQCAELGADI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LZTR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 17 nTPM
  • endometrium: 17 nTPM
  • colon: 15 nTPM
  • pituitary gland: 14 nTPM
  • adipose tissue: 14 nTPM
  • urinary bladder: 14 nTPM

Single-cell type

  • proximal tubule cells: 23 nCPM
  • bergmann glia: 22 nCPM
  • astrocytes: 21 nCPM
  • podocytes: 20 nCPM
  • somatotrophs: 19 nCPM
  • renal connecting tubule cells: 16 nCPM

Immune cell

  • non-classical monocyte: 1 nTPM
  • memory CD8 T-cell: 0.8 nTPM
  • gdT-cell: 0.7 nTPM
  • intermediate monocyte: 0.7 nTPM
  • classical monocyte: 0.5 nTPM
  • myeloid DC: 0.5 nTPM

Brain region

  • pons: 23 nTPM
  • midbrain: 21 nTPM
  • cerebral cortex: 21 nTPM
  • medulla oblongata: 20 nTPM
  • white matter: 20 nTPM
  • hypothalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about LZTR1.

Disease | AllUniProt

Conditions LZTR1 is implicated in, by any mechanism.

Disease | GeneticClinVar

799 pathogenic / likely-pathogenic of 4,639 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.99
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LZTR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LZTR1 as an antibody target. Whether an autoantibody or antibody against LZTR1 could matter depends on whether native LZTR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LZTR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LZTR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LZTR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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