Seroatlas · Human Serome Atlas

KLHL23

Kelch-like protein 23

Also known as: FLJ37812, KLH23_HUMAN, MGC22679, MGC2610

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NBE8
Gene
KLHL23
Ensembl
ENSG00000213160
Chromosome
2
Canonical length
558 aa
Protein class
Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Actin filaments

OverviewNCBI Gene

This locus represents naturally occurring read-through transcription between the neighboring PHOSPHO2 (phosphatase, orphan 2) and KLHL23 (kelch-like 23) genes on chromosome 2. The read-through transcript includes only non-coding PHOSPHO2 exons, and thus encodes the KLHL23 protein. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

558 residues, UniProt reviewed canonical sequence.

>Q8NBE8|KLHL23
     1  MALKGQEDYI YLFKDSTHPV DFLDAFRTFY LDGLFTDITL QCPSGIIFHC HRAVLAACSN
    61  YFKAMFTADM KEKFKNKIKL SGIHHDILEG LVNYAYTSQI EITKRNVQSL LEAADLLQFL
   121  SVKKACERFL VRHLDIDNCI GMHSFAEFHV CPELEKESRR ILCSKFKEVW QQEEFLEISL
   181  EKFLFILSRK NLSVWKEEAI IEPVIKWTAH DVENRIECLY NLLSYINIDI DPVYLKTALG
   241  LQRSCLLTEN KIRSLIYNAL NPMHKEISQR STATMYIIGG YYWHPLSEVH IWDPLTNVWI
   301  QGAEIPDYTR ESYGVTCLGP NIYVTGGYRT DNIEALDTVW IYNSESDEWT EGLPMLNARY
   361  YHCAVTLGGC VYALGGYRKG APAEEAEFYD PLKEKWIPIA NMIKGVGNAT ACVLHDVIYV
   421  IGGHCGYRGS CTYDKVQSYN SDINEWSLIT SSPHPEYGLC SVPFENKLYL VGGQTTITEC
   481  YDPEQNEWRE IAPMMERRME CGAVIMNGCI YVTGGYSYSK GTYLQSIEKY DPDLNKWEIV
   541  GNLPSAMRSH GCVCVYNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 24 nTPM
  • smooth muscle: 23 nTPM
  • colon: 19 nTPM
  • ovary: 19 nTPM
  • tongue: 15 nTPM
  • cerebral cortex: 14 nTPM

Single-cell type

  • retinal bipolar cells: 244 nCPM
  • cone photoreceptor cells: 201 nCPM
  • vascular smooth muscle cells: 187 nCPM
  • pericytes: 166 nCPM
  • oligodendrocyte progenitor cells: 161 nCPM
  • bergmann glia: 145 nCPM

Immune cell

  • NK-cell: 3.4 nTPM
  • naive CD4 T-cell: 1 nTPM
  • naive CD8 T-cell: 1 nTPM
  • MAIT T-cell: 0.9 nTPM
  • plasmacytoid DC: 0.9 nTPM
  • T-reg: 0.8 nTPM

Brain region

  • cerebellum: 37 nTPM
  • cerebral cortex: 30 nTPM
  • hippocampal formation: 30 nTPM
  • basal ganglia: 29 nTPM
  • hypothalamus: 25 nTPM
  • amygdala: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
0.73

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL23 as an antibody target. Whether an autoantibody or antibody against KLHL23 could matter depends on whether native KLHL23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL23. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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