Seroatlas · Human Serome Atlas

KLHL8

Kelch-like protein 8

Also known as: KIAA1378, KLHL8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2G9
Gene
KLHL8
Ensembl
ENSG00000145332
Chromosome
4
Canonical length
620 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

620 residues, UniProt reviewed canonical sequence.

>Q9P2G9|KLHL8
     1  MASDSMSSKQ ARNHITKGKR QQQHQQIKNR SSISDGDGED SFIFEANEAW KDFHGSLLRF
    61  YENGELCDVT LKVGSKLISC HKLVLACVIP YFRAMFLSEM AEAKQTLIEI RDFDGDAIED
   121  LVKFVYSSRL TLTVDNVQPL LYAACILQVE LVARACCEYM KLHFHPSNCL AVRAFAESHN
   181  RIDLMDMADQ YACDHFTEVV ECEDFVSVSP QHLHKLLSSS DLNIENEKQV YNAAIKWLLA
   241  NPQHHSKWLD ETLAQVRLPL LPVDFLMGVV AKEQIVKQNL KCRDLLDEAR NYHLHLSSRA
   301  VPDFEYSIRT TPRKHTAGVL FCVGGRGGSG DPFRSIECYS INKNSWFFGP EMNSRRRHVG
   361  VISVEGKVYA VGGHDGNEHL GSMEMFDPLT NKWMMKASMN TKRRGIALAS LGGPIYAIGG
   421  LDDNTCFNDV ERYDIESDQW STVAPMNTPR GGVGSVALVN HVYAVGGNDG MASLSSVERY
   481  DPHLDKWIEV KEMGQRRAGN GVSKLHGCLY VVGGFDDNSP LSSVERYDPR SNKWDYVAAL
   541  TTPRGGVGIA TVMGKIFAVG GHNGNAYLNT VEAFDPVLNR WELVGSVSHC RAGAGVAVCS
   601  CLTSQIRDVG HGSNNVVDCM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 57 nTPM
  • retina: 25 nTPM
  • thyroid gland: 18 nTPM
  • skeletal muscle: 13 nTPM
  • kidney: 11 nTPM
  • liver: 11 nTPM

Single-cell type

  • müller glia: 596 nCPM
  • epididymal principal cells: 323 nCPM
  • renal collecting duct principal cells: 310 nCPM
  • neutrophils: 282 nCPM
  • monocyte progenitors: 147 nCPM
  • rod photoreceptor cells: 128 nCPM

Immune cell

  • classical monocyte: 12 nTPM
  • myeloid DC: 10 nTPM
  • non-classical monocyte: 9.8 nTPM
  • intermediate monocyte: 9.2 nTPM
  • neutrophil: 8.6 nTPM
  • NK-cell: 8.4 nTPM

Brain region

  • cerebellum: 19 nTPM
  • hypothalamus: 17 nTPM
  • midbrain: 16 nTPM
  • white matter: 15 nTPM
  • thalamus: 15 nTPM
  • spinal cord: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.75
gnomAD pLI
0
gnomAD missense Z
2.23
DepMap mean gene effect
0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL8 as an antibody target. Whether an autoantibody or antibody against KLHL8 could matter depends on whether native KLHL8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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