ZBTB11

Protein identityUniProt · HPA

UniProt accession

O95625

Gene

ZBTB11

Ensembl

ENSG00000066422

Chromosome

3

Canonical length

1053 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleoplasm. Implicated in autosomal recessive intellectual developmental disorder 69. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1053 residues, UniProt reviewed canonical sequence.

>O95625|ZBTB11
     1  MSSEESYRAI LRYLTNEREP YAPGTEGNVK RKIRKAAACY VVRGGTLYYQ RRQRHRKTFA
    61  ELEVVLQPER RRDLIEAAHL GPGGTHHTRH QTWHYLSKTY WWRGILKQVK DYIKQCSKCQ
   121  EKLDRSRPIS DVSEMLEELG LDLESGEESN ESEDDLSNFT SSPTTASKPA KKKPVSKHEL
   181  VFVDTKGVVK RSSPKHCQAV LKQLNEQRLS NQFCDVTLLI EGEEYKAHKS VLSANSEYFR
   241  DLFIEKGAVS SHEAVVDLSG FCKASFLPLL EFAYTSVLSF DFCSMADVAI LARHLFMSEV
   301  LEICESVHKL MEEKQLTVYK KGEVQTVAST QDLRVQNGGT APPVASSEGT TTSLPTELGD
   361  CEIVLLVNGE LPEAEQNGEV GRQPEPQVSS EAESALSSVG CIADSHPEME SVDLITKNNQ
   421  TELETSNNRE NNTVSNIHPK LSKENVISSS PEDSGMGNDI SAEDICAEDI PKHRQKVDQP
   481  LKDQENLVAS TAKTDFGPDD DTYRSRLRQR SVNEGAYIRL HKGMEKKLQK RKAVPKSAVQ
   541  QVAQKLVQRG KKMKQPKRDA KENTEEASHK CGECGMVFQR RYALIMHKLK HERARDYKCP
   601  LCKKQFQYSA SLRAHLIRHT RKDAPSSSSS NSTSNEASGT SSEKGRTKRE FICSICGRTL
   661  PKLYSLRIHM LKHTGVKPHA CQVCGKTFIY KHGLKLHQSL HQSQKQFQCE LCVKSFVTKR
   721  SLQEHMSIHT GESKYLCSVC GKSFHRGSGL SKHFKKHQPK PEVRGYHCTQ CEKSFFEARD
   781  LRQHMNKHLG VKPFQCQFCD KCYSWKKDWY SHVKSHSVTE PYRCNICGKE FYEKALFRRH
   841  VKKATHGKKG RAKQNLERVC EKCGRKFTQL REYRRHMNNH EGVKPFECLT CGVAWADARS
   901  LKRHVRTHTG ERPYVCPVCS EAYIDARTLR KHMTKFHRDY VPCKIMLEKD TLQFHNQGTQ
   961  VAHAVSILTA GMQEQESSGP QELETVVVTG ETMEALEAVA ATEEYPSVST LSDQSIMQVV
  1021  NYVLAQQQGQ KLSEVAEAIQ TVKVEVAHIS GGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.51

Highest tissue expression

15 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZBTB11.

Disease | AllUniProt

Conditions ZBTB11 is implicated in, by any mechanism.

• Neurodevelopmental disorder with progressive movement abnormalities, cognitive decline, and brain abnormalities (NEDMCB) MIM:618383

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 178 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Intellectual developmental disorder, autosomal recessive 69

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.54

gnomAD pLI

0

gnomAD missense Z

2.05

DepMap mean gene effect

-1.25

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• regulation of DNA-templated transcription

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II cis-regulatory region sequence-specific DNA binding
• zinc ion binding

Cellular components

• nucleolus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• BTB/POZ domain
• SKP1/BTB/POZ domain superfamily
• Zinc finger C2H2-type
• Zinc finger C2H2 superfamily
• Integrase zinc-binding domain
• Zinc finger, C2H2 type
• BTB/POZ domain
• C2H2-type zinc finger
• Integrase zinc binding domain
• Zinc finger and BTB domain-containing protein 11, BTB/POZ domain

KeywordsUniProt

• DNA-binding
• Intellectual disability
• Isopeptide bond
• Metal-binding
• Nucleus
• Phosphoprotein
• Repeat
• Transcription
• Transcription regulation
• Ubl conjugation
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ZBTB11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• LIN28A