Seroatlas · Human Serome Atlas

BACH1

Transcription regulator protein BACH1

Also known as: BACH-1, BACH1_HUMAN, BTBD24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O14867
Gene: BACH1
Ensembl: ENSG00000156273
Chromosome: 21
Canonical length: 736 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

736 residues, UniProt reviewed canonical sequence.

>O14867|BACH1
     1  MSLSENSVFA YESSVHSTNV LLSLNDQRKK DVLCDVTIFV EGQRFRAHRS VLAACSSYFH
    61  SRIVGQADGE LNITLPEEVT VKGFEPLIQF AYTAKLILSK ENVDEVCKCV EFLSVHNIEE
   121  SCFQFLKFKF LDSTADQQEC PRKKCFSSHC QKTDLKLSLL DQRDLETDEV EEFLENKNVQ
   181  TPQCKLRRYQ GNAKASPPLQ DSASQTYESM CLEKDAALAL PSLCPKYRKF QKAFGTDRVR
   241  TGESSVKDIH ASVQPNERSE NECLGGVPEC RDLQVMLKCD ESKLAMEPEE TKKDPASQCP
   301  TEKSEVTPFP HNSSIDPHGL YSLSLLHTYD QYGDLNFAGM QNTTVLTEKP LSGTDVQEKT
   361  FGESQDLPLK SDLGTREDSS VASSDRSSVE REVAEHLAKG FWSDICSTDT PCQMQLSPAV
   421  AKDGSEQISQ KRSECPWLGI RISESPEPGQ RTFTTLSSVN CPFISTLSTE GCSSNLEIGN
   481  DDYVSEPQQE PCPYACVISL GDDSETDTEG DSESCSAREQ ECEVKLPFNA QRIISLSRND
   541  FQSLLKMHKL TPEQLDCIHD IRRRSKNRIA AQRCRKRKLD CIQNLESEIE KLQSEKESLL
   601  KERDHILSTL GETKQNLTGL CQKVCKEAAL SQEQIQILAK YSAADCPLSF LISEKDKSTP
   661  DGELALPSIF SLSDRPPAVL PPCARGNSEP GYARGQESQQ MSTATSEQAG PAEQCRQSGG
   721  ISDFCQQMTD KCTTDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BACH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 84 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 84 nTPM
placenta: 48 nTPM
liver: 29 nTPM
urinary bladder: 28 nTPM
appendix: 26 nTPM
testis: 25 nTPM

Single-cell type

neutrophils: 948 nCPM
podocytes: 817 nCPM
monocytes: 780 nCPM
late spermatids: 652 nCPM
microglia: 485 nCPM
cdc: 456 nCPM

Immune cell

neutrophil: 151 nTPM
basophil: 73 nTPM
classical monocyte: 51 nTPM
non-classical monocyte: 46 nTPM
intermediate monocyte: 40 nTPM
eosinophil: 39 nTPM

Brain region

pons: 114 nTPM
midbrain: 111 nTPM
cerebellum: 99 nTPM
medulla oblongata: 97 nTPM
hypothalamus: 88 nTPM
thalamus: 87 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.57
gnomAD missense Z: 0.56
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BACH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BACH1 as an antibody target. Whether an autoantibody or antibody against BACH1 could matter depends on whether native BACH1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BACH1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BACH1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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