Seroatlas · Human Serome Atlas

ZBTB7C

Zinc finger and BTB domain-containing protein 7C

Also known as: ZBT7C_HUMAN, ZBTB36, ZNF857C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1YPR0
Gene: ZBTB7C
Ensembl: ENSG00000184828
Chromosome: 18
Canonical length: 619 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell population proliferation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

619 residues, UniProt reviewed canonical sequence.

>A1YPR0|ZBTB7C
     1  MANDIDELIG IPFPNHSSEV LCSLNEQRHD GLLCDVLLVV QEQEYRTHRS VLAACSKYFK
    61  KLFTAGTLAS QPYVYEIDFV QPEALAAILE FAYTSTLTIT AGNVKHILNA ARMLEIQCIV
   121  NVCLEIMEPG GDGGEEDDKE DDDDDEDDDD EEDEEEEEEE EEDDDDDTED FADQENLPDP
   181  QDISCHQSPS KTDHLTEKAY SDTPRDFPDS FQAGSPGHLG VIRDFSIESL LRENLYPKAN
   241  IPDRRPSLSP FAPDFFPHLW PGDFGAFAQL PEQPMDSGPL DLVIKNRKIK EEEKEELPPP
   301  PPPPFPNDFF KDMFPDLPGG PLGPIKAEND YGAYLNFLSA THLGGLFPPW PLVEERKLKP
   361  KASQQCPICH KVIMGAGKLP RHMRTHTGEK PYMCTICEVR FTRQDKLKIH MRKHTGERPY
   421  LCIHCNAKFV HNYDLKNHMR IHTGVRPYQC EFCYKSFTRS DHLHRHIKRQ SCRMARPRRG
   481  RKPAAWRAAS LLFGPGGPAP DKAAFVMPPA LGEVGGHLGG AAVCLPGPSP AKHFLAAPKG
   541  ALSLQELERQ FEETQMKLFG RAQLEAERNA GGLLAFALAE NVAAARPYFP LPDPWAAGLA
   601  GLPGLAGLNH VASMSEANN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB7C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

esophagus: 39 nTPM
skin: 21 nTPM
vagina: 18 nTPM
epididymis: 16 nTPM
thyroid gland: 16 nTPM
colon: 14 nTPM

Single-cell type

sertoli cells: 552 nCPM
podocytes: 544 nCPM
retinal ganglion cells: 410 nCPM
papillary tip epithelial cells: 358 nCPM
vascular smooth muscle cells: 337 nCPM
adrenal cortex cells: 298 nCPM

Immune cell

basophil: 0.8 nTPM
non-classical monocyte: 0.5 nTPM
plasmacytoid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM

Brain region

thalamus: 48 nTPM
hypothalamus: 41 nTPM
medulla oblongata: 33 nTPM
basal ganglia: 33 nTPM
midbrain: 31 nTPM
spinal cord: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0.16
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB7C as an antibody target. Whether an autoantibody or antibody against ZBTB7C could matter depends on whether native ZBTB7C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB7C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB7C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...