Seroatlas · Human Serome Atlas

KCNC4

Voltage-gated potassium channel KCNC4

Also known as: C1orf30, HKSHIIIC, KCNC4_HUMAN, Kv3.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q03721
Gene
KCNC4
Ensembl
ENSG00000116396
Chromosome
1
Canonical length
635 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels
Subcellular location
Nucleoli,Cytosol
Quaternary structure
Homotetramer

OverviewNCBI Gene

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

635 residues, UniProt reviewed canonical sequence.

>Q03721|KCNC4
     1  MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY RSTLRTLPGT
    61  RLAWLADPDG GGRPETDGGG VGSSGSSGGG GCEFFFDRHP GVFAYVLNYY RTGKLHCPAD
   121  VCGPLFEEEL TFWGIDETDV EPCCWMTYRQ HRDAEEALDI FESPDGGGSG AGPSDEAGDD
   181  ERELALQRLG PHEGGAGHGA GSGGCRGWQP RMWALFEDPY SSRAARVVAF ASLFFILVSI
   241  TTFCLETHEA FNIDRNVTEI LRVGNITSVH FRREVETEPI LTYIEGVCVL WFTLEFLVRI
   301  VCCPDTLDFV KNLLNIIDFV AILPFYLEVG LSGLSSKAAR DVLGFLRVVR FVRILRIFKL
   361  TRHFVGLRVL GHTLRASTNE FLLLIIFLAL GVLIFATMIY YAERIGARPS DPRGNDHTDF
   421  KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM LVGALCALAG VLTIAMPVPV IVNNFGMYYS
   481  LAMAKQKLPK KRKKHVPRPA QLESPMYCKS EETSPRDSTC SDTSPPAREE GMIERKRADS
   541  KQNGDANAVL SDEEGAGLTQ PLASSPTPEE RRALRRSTTR DRNKKAAACF LLSTGDYACA
   601  DGSVRKGTFV LRDLPLQHSP EAACPPTAGT LFLPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 19 nTPM
  • hypothalamus: 17 nTPM
  • amygdala: 17 nTPM
  • hippocampal formation: 14 nTPM
  • cerebellum: 12 nTPM
  • kidney: 7.8 nTPM

Single-cell type

  • renal connecting tubule cells: 95 nCPM
  • renal collecting duct intercalated cells: 93 nCPM
  • adrenal medulla cells: 75 nCPM
  • rod photoreceptor cells: 74 nCPM
  • distal convoluted tubule cells: 55 nCPM
  • lacrimal acinar cells: 53 nCPM

Immune cell

  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • pons: 84 nTPM
  • amygdala: 84 nTPM
  • hippocampal formation: 74 nTPM
  • medulla oblongata: 65 nTPM
  • midbrain: 59 nTPM
  • cerebral cortex: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.73
gnomAD pLI
0
gnomAD missense Z
2.06
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNC4 as an antibody target. Whether an autoantibody or antibody against KCNC4 could matter depends on whether native KCNC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNC4 is annotated at the cell surface, where native KCNC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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