Seroatlas · Human Serome Atlas

RCBTB2

RCC1 and BTB domain-containing protein 2

Also known as: CHC1L, RCBT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95199
Gene
RCBTB2
Ensembl
ENSG00000136161
Chromosome
13
Canonical length
551 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Canonical amino-acid sequenceUniProt

551 residues, UniProt reviewed canonical sequence.

>O95199|RCBTB2
     1  MEEELPLFSG DSGKPVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV FGSAGNEVLY
    61  TTVNDEIFVL GTNCCGCLGL GDVQSTIEPR RLDSLNGKKI ACLSYGSGPH IVLATTEGEV
   121  FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS NKQVIEVACG SYHSLVLTSD GEVFAWGYNN
   181  SGQVGSGSTV NQPIPRRVTG CLQNKVVVTI ACGQMCCMAV VDTGEVYVWG YNGNGQLGLG
   241  NSGNQPTPCR VAALQGIRVQ RVACGYAHTL VLTDEGQVYA WGANSYGQLG TGNKSNQSYP
   301  TPVTVEKDRI IEIAACHSTH TSAAKTQGGH VYMWGQCRGQ SVILPHLTHF SCTDDVFACF
   361  ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV DGKYIYAHKV LLKIRCEHFR
   421  SSLEDNEDDI VEMSEFSYPV YRAFLEYLYT DSISLSPEEA VGLLDLATFY RENRLKKLCQ
   481  QTIKQGICEE NAIALLSAAV KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI
   541  SKASRVGAFK N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCBTB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 26 nTPM
  • ovary: 23 nTPM
  • salivary gland: 22 nTPM
  • seminal vesicle: 19 nTPM
  • placenta: 17 nTPM
  • spleen: 16 nTPM

Single-cell type

  • microglia: 164 nCPM
  • thymocytes: 164 nCPM
  • neutrophils: 101 nCPM
  • monocytes: 78 nCPM
  • macrophages: 76 nCPM
  • choroid plexus epithelial cells: 69 nCPM

Immune cell

  • neutrophil: 55 nTPM
  • classical monocyte: 40 nTPM
  • intermediate monocyte: 29 nTPM
  • non-classical monocyte: 28 nTPM
  • myeloid DC: 27 nTPM
  • total PBMC: 21 nTPM

Brain region

  • choroid plexus: 26 nTPM
  • white matter: 19 nTPM
  • hypothalamus: 17 nTPM
  • spinal cord: 17 nTPM
  • medulla oblongata: 15 nTPM
  • midbrain: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.95
gnomAD pLI
0
gnomAD missense Z
-0.06
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RCBTB2 as an antibody target. Whether an autoantibody or antibody against RCBTB2 could matter depends on whether native RCBTB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RCBTB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RCBTB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RCBTB2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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