Seroatlas · Human Serome Atlas

ZBTB17

Zinc finger and BTB domain-containing protein 17

Also known as: MIZ1, pHZ-67, ZBT17_HUMAN, ZNF151, ZNF60

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q13105
Gene: ZBTB17
Ensembl: ENSG00000116809
Chromosome: 1
Canonical length: 803 aa
Protein class: Predicted intracellular proteins, Transcription factors
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

803 residues, UniProt reviewed canonical sequence.

>Q13105|ZBTB17
     1  MDFPQHSQHV LEQLNQQRQL GLLCDCTFVV DGVHFKAHKA VLAACSEYFK MLFVDQKDVV
    61  HLDISNAAGL GQVLEFMYTA KLSLSPENVD DVLAVATFLQ MQDIITACHA LKSLAEPATS
   121  PGGNAEALAT EGGDKRAKEE KVATSTLSRL EQAGRSTPIG PSRDLKEERG GQAQSAASGA
   181  EQTEKADAPR EPPPVELKPD PTSGMAAAEA EAALSESSEQ EMEVEPARKG EEEQKEQEEQ
   241  EEEGAGPAEV KEEGSQLENG EAPEENENEE SAGTDSGQEL GSEARGLRSG TYGDRTESKA
   301  YGSVIHKCED CGKEFTHTGN FKRHIRIHTG EKPFSCRECS KAFSDPAACK AHEKTHSPLK
   361  PYGCEECGKS YRLISLLNLH KKRHSGEARY RCEDCGKLFT TSGNLKRHQL VHSGEKPYQC
   421  DYCGRSFSDP TSKMRHLETH DTDKEHKCPH CDKKFNQVGN LKAHLKIHIA DGPLKCRECG
   481  KQFTTSGNLK RHLRIHSGEK PYVCIHCQRQ FADPGALQRH VRIHTGEKPC QCVMCGKAFT
   541  QASSLIAHVR QHTGEKPYVC ERCGKRFVQS SQLANHIRHH DNIRPHKCSV CSKAFVNVGD
   601  LSKHIIIHTG EKPYLCDKCG RGFNRVDNLR SHVKTVHQGK AGIKILEPEE GSEVSVVTVD
   661  DMVTLATEAL AATAVTQLTV VPVGAAVTAD ETEVLKAEIS KAVKQVQEED PNTHILYACD
   721  SCGDKFLDAN SLAQHVRIHT AQALVMFQTD ADFYQQYGPG GTWPAGQVLQ AGELVFRPRD
   781  GAEGQPALAE TSPTAPECPP PAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
spleen: 28 nTPM
bone marrow: 27 nTPM
skeletal muscle: 26 nTPM
hippocampal formation: 24 nTPM
basal ganglia: 23 nTPM

Single-cell type

epicardial cells: 80 nCPM
late primary spermatocytes: 57 nCPM
esophageal apical cells: 50 nCPM
b-cells: 33 nCPM
hepatic stellate cells: 32 nCPM
early primary spermatocytes: 32 nCPM

Immune cell

neutrophil: 11 nTPM
NK-cell: 9.7 nTPM
memory B-cell: 8.7 nTPM
memory CD8 T-cell: 8 nTPM
gdT-cell: 7.6 nTPM
eosinophil: 6.7 nTPM

Brain region

white matter: 24 nTPM
cerebral cortex: 21 nTPM
basal ganglia: 20 nTPM
medulla oblongata: 20 nTPM
midbrain: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.31
gnomAD pLI: 0.98
gnomAD missense Z: 3.73
DepMap mean gene effect: -0.64
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB17 as an antibody target. Whether an autoantibody or antibody against ZBTB17 could matter depends on whether native ZBTB17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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