Seroatlas · Human Serome Atlas

KCTD12

BTB/POZ domain-containing protein KCTD12

Also known as: C13orf2, KCD12_HUMAN, KIAA1778, PFET1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96CX2
Gene
KCTD12
Ensembl
ENSG00000178695
Chromosome
13
Canonical length
325 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cell projection; plasma membrane; and synapse. Predicted to be part of receptor complex. Predicted to be active in GABA-ergic synapse; postsynaptic membrane; and presynaptic active zone membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q96CX2|KCTD12
     1  MALADSTRGL PNGGGGGGGS GSSSSSAEPP LFPDIVELNV GGQVYVTRRC TVVSVPDSLL
    61  WRMFTQQQPQ ELARDSKGRF FLDRDGFLFR YILDYLRDLQ LVLPDYFPER SRLQREAEYF
   121  ELPELVRRLG APQQPGPGPP PSRRGVHKEG SLGDELLPLG YSEPEQQEGA SAGAPSPTLE
   181  LASRSPSGGA AGPLLTPSQS LDGSRRSGYI TIGYRGSYTI GRDAQADAKF RRVARITVCG
   241  KTSLAKEVFG DTLNESRDPD RPPERYTSRY YLKFNFLEQA FDKLSESGFH MVACSSTGTC
   301  AFASSTDQSE DKIWTSYTEY VFCRE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 79 nTPM
  • adipose tissue: 71 nTPM
  • fallopian tube: 71 nTPM
  • ovary: 67 nTPM
  • spleen: 61 nTPM
  • smooth muscle: 61 nTPM

Single-cell type

  • kupffer cells: 524 nCPM
  • neuroendocrine cells: 406 nCPM
  • monocytes: 393 nCPM
  • hofbauer cells: 384 nCPM
  • macrophages: 301 nCPM
  • vascular endothelial cells: 284 nCPM

Immune cell

  • classical monocyte: 3.9 nTPM
  • myeloid DC: 3.7 nTPM
  • intermediate monocyte: 2.5 nTPM
  • plasmacytoid DC: 1.9 nTPM
  • non-classical monocyte: 1.5 nTPM
  • neutrophil: 1 nTPM

Brain region

  • spinal cord: 86 nTPM
  • medulla oblongata: 83 nTPM
  • white matter: 79 nTPM
  • midbrain: 77 nTPM
  • pons: 73 nTPM
  • thalamus: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0.06
gnomAD missense Z
0.76
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCTD12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD12 as an antibody target. Whether an autoantibody or antibody against KCTD12 could matter depends on whether native KCTD12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD12 is annotated at the cell surface, where native KCTD12 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCTD12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCTD12. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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