Seroatlas · Human Serome Atlas

KLHL31

Kelch-like protein 31

Also known as: bA345L23.2, BKLHD6, KBTBD1, KLH31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H511
Gene: KLHL31
Ensembl: ENSG00000124743
Chromosome: 6
Canonical length: 634 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in negative regulation of JNK cascade and negative regulation of protein phosphorylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

634 residues, UniProt reviewed canonical sequence.

>Q9H511|KLHL31
     1  MAPKKKIVKK NKGDINEMTI IVEDSPLNKL NALNGLLEGG NGLSCISSEL TDASYGPNLL
    61  EGLSKMRQEN FLCDLVIGTK TKSFDVHKSV MASCSEYFYN ILKKDPSIQR VDLNDISPLG
   121  LATVIAYAYT GKLTLSLYTI GSIISAAVYL QIHTLVKMCS DFLIREMSVE NCMYVVNIAE
   181  TYSLKNAKAA AQKFIRDNFL EFAESDQFMK LTFEQINELL IDDDLQLPSE IVAFQIAMKW
   241  LEFDQKRVKY AADLLSNIRF GTISAQDLVN YVQSVPRMMQ DADCHRLLVD AMNYHLLPYH
   301  QNTLQSRRTR IRGGCRVLVT VGGRPGLTEK SLSRDILYRD PENGWSKLTE MPAKSFNQCV
   361  AVMDGFLYVA GGEDQNDARN QAKHAVSNFC RYDPRFNTWI HLASMNQKRT HFSLSVFNGL
   421  VYAAGGRNAE GSLASLECYV PSTNQWQPKT PLEVARCCHA SAVADGRVLV TGGYIANAYS
   481  RSVCAYDPAS DSWQELPNLS TPRGWHCAVT LSDRVYVMGG SQLGPRGERV DVLTVECYSP
   541  ATGQWSYAAP LQVGVSTAGV SALHGRAYLV GGWNEGEKKY KKCIQCFSPE LNEWTEDDEL
   601  PEATVGVSCC TLSMPNNVTR ESRASSVSSV PVSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 137 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 137 nTPM
heart muscle: 47 nTPM
tongue: 33 nTPM
adipose tissue: 8.1 nTPM
breast: 2.9 nTPM
prostate: 1.2 nTPM

Single-cell type

cardiomyocytes: 1,298 nCPM
myonuclei: 488 nCPM
epicardial cells: 212 nCPM
adipocytes: 139 nCPM
thymic myoid cells: 38 nCPM
mesothelial cells: 14 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.4 nTPM
basal ganglia: 1 nTPM
hypothalamus: 0.7 nTPM
medulla oblongata: 0.7 nTPM
white matter: 0.6 nTPM
spinal cord: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.77
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL31 as an antibody target. Whether an autoantibody or antibody against KLHL31 could matter depends on whether native KLHL31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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