Seroatlas · Human Serome Atlas

ZBTB32

Zinc finger and BTB domain-containing protein 32

Also known as: FAXF, FAZF, Rog, TZFP, ZBT32_HUMAN, ZNF538

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2Y4
Gene: ZBTB32
Ensembl: ENSG00000011590
Chromosome: 19
Canonical length: 487 aa
Protein class: Predicted intracellular proteins, Transcription factors
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q9Y2Y4|ZBTB32
     1  MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV SQQLGRRGQW
    61  ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL GVQSLEEACW RARGDRAKKP
   121  DPGLKKHQEE PEKPSRNPER ELGDPGEKQK PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA
   181  TQEAQQEQTR SKEKRLQAPV GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ
   241  TSVTPRPSWA EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN
   301  APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH EDKAGCPPRP
   361  HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP FSCSLCPQRS RDFSAMTKHL
   421  RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC
   481  CPSSSTT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

testis: 47 nTPM
lymph node: 3.2 nTPM
spleen: 2.4 nTPM
appendix: 1.8 nTPM
small intestine: 1.5 nTPM
tonsil: 1.2 nTPM

Single-cell type

late primary spermatocytes: 212 nCPM
late spermatids: 110 nCPM
early primary spermatocytes: 30 nCPM
mast cells: 27 nCPM
early spermatids: 27 nCPM
plasma cells: 18 nCPM

Immune cell

memory B-cell: 11 nTPM
naive B-cell: 3.9 nTPM
T-reg: 2.3 nTPM
memory CD8 T-cell: 0.6 nTPM
total PBMC: 0.6 nTPM
memory CD4 T-cell: 0.5 nTPM

Brain region

cerebellum: 6.1 nTPM
cerebral cortex: 3.3 nTPM
amygdala: 3.1 nTPM
medulla oblongata: 3 nTPM
white matter: 3 nTPM
basal ganglia: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.96
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB32 as an antibody target. Whether an autoantibody or antibody against ZBTB32 could matter depends on whether native ZBTB32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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