Seroatlas · Human Serome Atlas

KLHL42

Kelch-like protein 42

Also known as: Ctb9, KIAA1340, KLH42_HUMAN, KLHDC5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2K6
Gene
KLHL42
Ensembl
ENSG00000087448
Chromosome
12
Canonical length
505 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Contributes to ubiquitin-protein transferase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of microtubule-based process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>Q9P2K6|KLHL42
     1  MSAEEMVQIR LEDRCYPVSK RKLIEQSDYF RALYRSGMRE ALSQEAGGPE VQQLRGLSAP
    61  GLRLVLDFIN AGGAREGWLL GPRGEKGGGV DEDEEMDEVS LLSELVEAAS FLQVTSLLQL
   121  LLSQVRLNNC LEMYRLAQVY GLPDLQEACL RFMVVHFHEV LCKPQFHLLG SPPQAPGDVS
   181  LKQRLREARM TGTPVLVALG DFLGGPLAPH PYQGEPPSML RYEEMTERWF PLANNLPPDL
   241  VNVRGYGSAI LDNYLFIVGG YRITSQEISA AHSYNPSTNE WLQVASMNQK RSNFKLVAVN
   301  SKLYAIGGQA VSNVECYNPE QDAWNFVAPL PNPLAEFSAC ECKGKIYVIG GYTTRDRNMN
   361  ILQYCPSSDM WTLFETCDVH IRKQQMVSVE ETIYIVGGCL HELGPNRRSS QSEDMLTVQS
   421  YNTVTRQWLY LKENTSKSGL NLTCALHNDG IYIMSRDVTL STSLEHRVFL KYNIFSDSWE
   481  AFRRFPAFGH NLLVSSLYLP NKAET

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 31 nTPM
  • colon: 22 nTPM
  • smooth muscle: 22 nTPM
  • urinary bladder: 21 nTPM
  • pancreas: 20 nTPM
  • cerebral cortex: 18 nTPM

Single-cell type

  • podocytes: 261 nCPM
  • peritubular myoid cells: 222 nCPM
  • sertoli cells: 195 nCPM
  • cytotrophoblasts: 122 nCPM
  • smooth muscle cells: 106 nCPM
  • oligodendrocytes: 98 nCPM

Immune cell

  • T-reg: 1.8 nTPM
  • memory CD4 T-cell: 1.1 nTPM
  • naive CD8 T-cell: 1.1 nTPM
  • gdT-cell: 1 nTPM
  • MAIT T-cell: 1 nTPM
  • naive CD4 T-cell: 0.8 nTPM

Brain region

  • white matter: 45 nTPM
  • cerebral cortex: 40 nTPM
  • hypothalamus: 38 nTPM
  • basal ganglia: 38 nTPM
  • thalamus: 37 nTPM
  • spinal cord: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.72
gnomAD pLI
0.01
gnomAD missense Z
1.54
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL42 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL42 as an antibody target. Whether an autoantibody or antibody against KLHL42 could matter depends on whether native KLHL42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL42. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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