Seroatlas · Human Serome Atlas

ZBTB40

Zinc finger and BTB domain-containing protein 40

Also known as: KIAA0478, ZBT40_HUMAN, ZNF923

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUA8
Gene: ZBTB40
Ensembl: ENSG00000184677
Chromosome: 1
Canonical length: 1239 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in DNA damage response. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1239 residues, UniProt reviewed canonical sequence.

>Q9NUA8|ZBTB40
     1  MELPNYSRQL LQQLYTLCKE QQFCDCTISI GTIYFRAHKL VLAAASLLFK TLLDNTDTIS
    61  IDASVVSPEE FALLLEMMYT GKLPVGKHNF SKIISLADSL QMFDVAVSCK NLLTSLVNCS
   121  VQGQVVRDVS APSSETFRKE PEKPQVEILS SEGAGEPHSS PELAATPGGP VKAETEEAAH
   181  SVSQEMSVNS PTAQESQRNA ETPAETPTTA EACSPSPAVQ TFSEAKKTST EPGCERKHYQ
   241  LNFLLENEGV FSDALMVTQD VLKKLEMCSE IKGPQKEMIV KCFEGEGGHS AFQRILGKVR
   301  EESLDVQTVV SLLRLYQYSN PAVKTALLDR KPEDVDTVQP KGSTEEGKTL SVLLLEHKED
   361  LIQCVTQLRP IMESLETAKE EFLTGTEKRV ILNCCEGRTP KETIENLLHR MTEEKTLTAE
   421  GLVKLLQAVK TTFPNLGLLL EKLQKSATLP STTVQPSPDD YGTELLRRYH ENLSEIFTDN
   481  QILLKMISHM TSLAPGEREV MEKLVKRDSG SGGFNSLISA VLEKQTLSAT AIWQLLLVVQ
   541  ETKTCPLDLL MEEIRREPGA DAFFRAVTTP EHATLETILR HNQLILEAIQ QKIEYKLFTS
   601  EEEHLAETVK EILSIPSETA SPEASLRAVL SRAMEKSVPA IEICHLLCSV HKSFPGLQPV
   661  MQELAYIGVL TKEDGEKETW KVSNKFHLEA NNKEDEKAAK EDSQPGEQND QGETGSLPGQ
   721  QEKEASASPD PAKKSFICKA CDKSFHFYCR LKVHMKRCRV AKSKQVQCKE CSETKDSKKE
   781  LDKHQLEAHG AGGEPDAPKK KKKRLPVTCD LCGREFAHAS GMQYHKLTEH FDEKPFSCEE
   841  CGAKFAANST LKNHLRLHTG DRPFMCKHCL MTFTQASALA YHTKKKHSEG KMYACQYCDA
   901  VFAQSIELSR HVRTHTGDKP YVCRDCGKGF RQANGLSIHL HTFHNIEDPY DCKKCRMSFP
   961  TLQDHRKHIH EVHSKEYHPC PTCGKIFSAP SMLERHVVTH VGGKPFSCGI CNKAYQQLSG
  1021  LWYHNRTHHP DVFAAQNHRS SKFSSLQCSS CDKTFPNTIE HKKHIKAEHA DMKFHECDQC
  1081  KELFPTPALL QVHVKCQHSG SQPFRCLYCA ATFRFPGALQ HHVTTEHFKQ SETTFPCELC
  1141  GELFTSQAQL DSHLESEHPK VMSTETQAAA SQMAQVIQTP EPVAPTEQVI TLEETQLAGS
  1201  QVFVTLPDSQ ASQASSELVA VTVEDLLDGT VTLICGEAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

spleen: 17 nTPM
adrenal gland: 14 nTPM
blood vessel: 14 nTPM
tonsil: 14 nTPM
small intestine: 14 nTPM
lymph node: 13 nTPM

Single-cell type

thyrotrophs: 94 nCPM
somatotrophs: 89 nCPM
adrenal medulla cells: 85 nCPM
lactotrophs: 82 nCPM
adrenal cortex cells: 81 nCPM
gonadotrophs: 68 nCPM

Immune cell

NK-cell: 2.9 nTPM
T-reg: 1.4 nTPM
MAIT T-cell: 1.3 nTPM
intermediate monocyte: 1.2 nTPM
naive B-cell: 1.1 nTPM
basophil: 1 nTPM

Brain region

choroid plexus: 23 nTPM
spinal cord: 22 nTPM
white matter: 21 nTPM
midbrain: 20 nTPM
medulla oblongata: 19 nTPM
pons: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

BTB/POZ domain
SKP1/BTB/POZ domain superfamily
Zinc finger C2H2-type
Zinc finger C2H2 superfamily
Zinc finger, C2H2 type
BTB/POZ domain
Zinc-finger of C2H2 type
Zinc finger and BTB domain-containing protein 40, BTB/POZ domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB40 as an antibody target. Whether an autoantibody or antibody against ZBTB40 could matter depends on whether native ZBTB40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB40 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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