Seroatlas · Human Serome Atlas

ZBTB49

Zinc finger and BTB domain-containing protein 49

Also known as: FLJ38559, ZBT49_HUMAN, ZNF509

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZSB9
Gene: ZBTB49
Ensembl: ENSG00000168826
Chromosome: 4
Canonical length: 765 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Microtubules,Cytosol

OverviewNCBI Gene

Enables DNA-binding transcription factor binding activity; sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle. Located in cytosol; microtubule cytoskeleton; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

765 residues, UniProt reviewed canonical sequence.

>Q6ZSB9|ZBTB49
     1  MDPVATHSCH LLQQLHEQRI QGLLCDCMLV VKGVCFKAHK NVLAAFSQYF RSLFQNSSSQ
    61  KNDVFHLDVK NVSGIGQILD FMYTSHLDLN QDNIQVMLDT AQCLQVQNVL SLCHTFLKSA
   121  TVVQPPGMPC NSTLSLQSTL TPDATCVISE NYPPHLLQEC SADAQQNKTL DESHPHASPS
   181  VNRHHSAGEI SKQAPDTSDG SCTELPFKQP NYYYKLRNFY SKQYHKHAAG PSQERVVEQP
   241  FAFSTSTDLT TVESQPCAVS HSECILESPE HLPSNFLAQP VNDSAPHPES DATCQQPVKQ
   301  MRLKKAIHLK KLNFLKSQKY AEQVSEPKSD DGLTKRLESA SKNTLEKASS QSAEEKESEE
   361  VVSCENFNCI SETERPEDPA ALEDQSQTLQ SQRQYACELC GKPFKHPSNL ELHKRSHTGE
   421  KPFECNICGK HFSQAGNLQT HLRRHSGEKP YICEICGKRF AASGDVQRHI IIHSGEKPHL
   481  CDICGRGFSN FSNLKEHKKT HTADKVFTCD ECGKSFNMQR KLVKHRIRHT GERPYSCSAC
   541  GKCFGGSGDL RRHVRTHTGE KPYTCEICNK CFTRSAVLRR HKKMHCKAGD ESPDVLEELS
   601  QAIETSDLEK SQSSDSFSQD TSVTLMPVSV KLPVHPVENS VAEFDSHSGG SYCKLRSMIQ
   661  PHGVSDQEKL SLDPGKLAKP QMQQTQPQAY AYSDVDTPAG GEPLQADGMA MIRSSLAALD
   721  NHGGDPLGSR ASSTTYRNSE GQFFSSMTLW GLAMKTLQNE NELDQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB49 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 4.8 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 4.8 nTPM
testis: 3.7 nTPM
spleen: 3.3 nTPM
retina: 3.2 nTPM
pituitary gland: 2.9 nTPM
lymph node: 2.8 nTPM

Single-cell type

myonuclei: 35 nCPM
cone photoreceptor cells: 33 nCPM
corticotrophs: 32 nCPM
gonadotrophs: 26 nCPM
rod photoreceptor cells: 19 nCPM
brain inhibitory neurons: 16 nCPM

Immune cell

eosinophil: 9.8 nTPM
gdT-cell: 4.6 nTPM
neutrophil: 4.6 nTPM
memory CD8 T-cell: 4.5 nTPM
MAIT T-cell: 3.8 nTPM
naive CD8 T-cell: 3.4 nTPM

Brain region

white matter: 8 nTPM
pons: 5.7 nTPM
choroid plexus: 5.6 nTPM
cerebellum: 5.3 nTPM
cerebral cortex: 5.3 nTPM
medulla oblongata: 5.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.66
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB49 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB49 as an antibody target. Whether an autoantibody or antibody against ZBTB49 could matter depends on whether native ZBTB49 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB49 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB49 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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