Seroatlas · Human Serome Atlas

KCTD19

BTB/POZ domain-containing protein KCTD19

Also known as: FLJ40162, KCD19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RG1
Gene: KCTD19
Ensembl: ENSG00000168676
Chromosome: 16
Canonical length: 926 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in male meiotic nuclear division. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

926 residues, UniProt reviewed canonical sequence.

>Q17RG1|KCTD19
     1  MEESGMAHES AEDLFHFNVG GWHFSVPRSK LSQFPDSLLW KEASALTSSE SQRLFIDRDG
    61  STFRHVHYYL YTSKLSFSSC AELNLLYEQA LGLQLMPLLQ TLDNLKEGKH HLRVRPADLP
   121  VAERASLNYW RTWKCISKPS EFPIKSPAFT GLHDKAPLGL MDTPLLDTEE EVHYCFLPLD
   181  LVAKYPSLVT EDNLLWLAET VALIECECSE FRFIVNFLRS QKILLPDNFS NIDVLEAEVE
   241  ILEIPALTEA VRWYRMNMGG CSPTTCSPLS PGKGARTASL ESVKPLYTMA LGLLVKYPDS
   301  ALGQLRIEST LDGSRLYITG NGVLFQHVKN WLGTCRLPLT ETISEVYELC AFLDKRDITY
   361  EPIKVALKTH LEPRTLAPMD VLNEWTAEIT VYSPQQIIKV YVGSHWYATT LQTLLKYPEL
   421  LSNPQRVYWI TYGQTLLIHG DGQMFRHILN FLRLGKLFLP SEFKEWPLFC QEVEEYHIPS
   481  LSEALAQCEA YKSWTQEKES ENEEAFSIRR LHVVTEGPGS LVEFSRDTKE TTAYMPVDFE
   541  DCSDRTPWNK AKGNLVRSNQ MDEAEQYTRP IQVSLCRNAK RAGNPSTYSH CRGLCTNPGH
   601  WGSHPESPPK KKCTTINLTQ KSETKDPPAT PMQKLISLVR EWDMVNCKQW EFQPLTATRS
   661  SPLEEATLQL PLGSEAASQP STSAAWKAHS TASEKDPGPQ AGAGAGAKDK GPEPTFKPYL
   721  PPKRAGTLKD WSKQRTKERE SPAPEQPLPE ASEVDSLGVI LKVTHPPVVG SDGFCMFFED
   781  SIIYTTEMDN LRHTTPTASP QPQEVTFLSF SLSWEEMFYA QKCHCFLADI IMDSIRQKDP
   841  KAITAKVVSL ANRLWTLHIS PKQFVVDLLA ITGFKDDRHT QERLYSWVEL TLPFARKYGR
   901  CMDLLIQRGL SRSVSYSILG KYLQED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

testis: 31 nTPM
bone marrow: 3.1 nTPM
skin: 1.6 nTPM
basal ganglia: 0.8 nTPM
epididymis: 0.8 nTPM
appendix: 0.6 nTPM

Single-cell type

early primary spermatocytes: 196 nCPM
late primary spermatocytes: 129 nCPM
early spermatids: 43 nCPM
pdcs: 16 nCPM
differentiating spermatogonia: 15 nCPM
mast cells: 9.8 nCPM

Immune cell

neutrophil: 2.7 nTPM
plasmacytoid DC: 2.7 nTPM
basophil: 1.5 nTPM
classical monocyte: 0.4 nTPM
naive B-cell: 0.4 nTPM
NK-cell: 0.4 nTPM

Brain region

white matter: 21 nTPM
thalamus: 19 nTPM
pons: 17 nTPM
medulla oblongata: 16 nTPM
cerebral cortex: 16 nTPM
cerebellum: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCTD19.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 134 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cerebral visual impairment and intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 1.29
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD19 as an antibody target. Whether an autoantibody or antibody against KCTD19 could matter depends on whether native KCTD19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KCTD19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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