Seroatlas · Human Serome Atlas

KCTD16

BTB/POZ domain-containing protein KCTD16

Also known as: KCD16_HUMAN, KIAA1317

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q68DU8
Gene
KCTD16
Ensembl
ENSG00000183775
Chromosome
5
Canonical length
428 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Centrosome,Mid piece,Principal piece,End piece
Quaternary structure
Homopentamer

OverviewNCBI Gene

Predicted to enable G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential; G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential; and identical protein binding activity. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within behavioral fear response and memory. Predicted to be located in cell projection; plasma membrane; and synapse. Predicted to be part of receptor complex. Predicted to be active in postsynaptic membrane and presynaptic membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q68DU8|KCTD16
     1  MALSGNCSRY YPREQGSAVP NSFPEVVELN VGGQVYFTRH STLISIPHSL LWKMFSPKRD
    61  TANDLAKDSK GRFFIDRDGF LFRYILDYLR DRQVVLPDHF PEKGRLKREA EYFQLPDLVK
   121  LLTPDEIKQS PDEFCHSDFE DASQGSDTRI CPPSSLLPAD RKWGFITVGY RGSCTLGREG
   181  QADAKFRRVP RILVCGRISL AKEVFGETLN ESRDPDRAPE RYTSRFYLKF KHLERAFDML
   241  SECGFHMVAC NSSVTASFIN QYTDDKIWSS YTEYVFYREP SRWSPSHCDC CCKNGKGDKE
   301  GESGTSCNDL STSSCDSQSE ASSPQETVIC GPVTRQTNIQ TLDRPIKKGP VQLIQQSEMR
   361  RKSDLLRTLT SGSRESNMSS KKKAVKEKLS IEEELEKCIQ DFLKIKIPDR FPERKHPWQS
   421  ELLRKYHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCTD16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
7.1 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 7.1 nTPM
  • hippocampal formation: 2.8 nTPM
  • amygdala: 2.2 nTPM
  • basal ganglia: 1.9 nTPM
  • retina: 1.8 nTPM
  • pancreas: 1.4 nTPM

Single-cell type

  • brain excitatory neurons: 645 nCPM
  • brain inhibitory neurons: 589 nCPM
  • oligodendrocyte progenitor cells: 492 nCPM
  • adrenal medulla cells: 436 nCPM
  • loop of henle epithelial cells: 203 nCPM
  • other brain neurons: 184 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 39 nTPM
  • hippocampal formation: 27 nTPM
  • white matter: 22 nTPM
  • basal ganglia: 21 nTPM
  • amygdala: 14 nTPM
  • midbrain: 9.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
0.99
gnomAD missense Z
1.23
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCTD16 as an antibody target. Whether an autoantibody or antibody against KCTD16 could matter depends on whether native KCTD16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCTD16 is annotated at the cell surface, where native KCTD16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCTD16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCTD16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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