Seroatlas · Human Serome Atlas

ZBTB37

Zinc finger and BTB domain-containing protein 37

Also known as: MGC2629, ZBT37_HUMAN, ZNF908

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5TC79
Gene: ZBTB37
Ensembl: ENSG00000185278
Chromosome: 1
Canonical length: 503 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in chromatin. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

503 residues, UniProt reviewed canonical sequence.

>Q5TC79|ZBTB37
     1  MEKGGNIQLE IPDFSNSVLS HLNQLRMQGR LCDIVVNVQG QAFRAHKVVL AASSPYFRDH
    61  MSLNEMSTVS ISVIKNPTVF EQLLSFCYTG RICLQLADII SYLTAASFLQ MQHIIDKCTQ
   121  ILEGIHFKIN VAEVEAELSQ TRTKHQERPP ESHRVTPNLN RSLSPRHNTP KGNRRGQVSA
   181  VLDIRELSPP EESTSPQIIE PSSDVESREP ILRINRAGQW YVETGVADRG GRSDDEVRVL
   241  GAVHIKTENL EEWLGPENQP SGEDGSSAEE VTAMVIDTTG HGSVGQENYT LGSSGAKVAR
   301  PTSSEVDRFS PSGSVVPLTE RHRARSESPG RMDEPKQPSS QVEESAMMGV SGYVEYLREQ
   361  EVSERWFRYN PRLTCIYCAK SFNQKGSLDR HMRLHMGITP FVCRMCGKKY TRKDQLEYHI
   421  RKHTGNKPFH CHVCGKSFPF QAILNQHFRK NHPGCIPLEG PHSISPETTV TSRGQAEEES
   481  PSQEETVAPG EAVQGSVSTT GPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 9.7 nTPM

Expression across tissuesHPA

Tissue

retina: 9.7 nTPM
testis: 8 nTPM
bone marrow: 5 nTPM
spleen: 3.4 nTPM
lymph node: 3.3 nTPM
skin: 2.9 nTPM

Single-cell type

late spermatids: 91 nCPM
neutrophils: 90 nCPM
bergmann glia: 83 nCPM
thyrotrophs: 66 nCPM
oligodendrocytes: 65 nCPM
late primary spermatocytes: 57 nCPM

Immune cell

neutrophil: 2.3 nTPM
eosinophil: 1.4 nTPM
gdT-cell: 1 nTPM
NK-cell: 0.9 nTPM
plasmacytoid DC: 0.9 nTPM
memory CD8 T-cell: 0.8 nTPM

Brain region

white matter: 34 nTPM
medulla oblongata: 28 nTPM
basal ganglia: 24 nTPM
pons: 23 nTPM
cerebellum: 23 nTPM
midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.34
gnomAD pLI: 0.96
gnomAD missense Z: 2.36
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB37 as an antibody target. Whether an autoantibody or antibody against ZBTB37 could matter depends on whether native ZBTB37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...