KCTD5
BTB/POZ domain-containing protein KCTD5
Also known as: FLJ20040, KCTD5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NXV2
- Gene
- KCTD5
- Ensembl
- ENSG00000167977
- Chromosome
- 16
- Canonical length
- 234 aa
- Protein class
- Predicted intracellular proteins
- Quaternary structure
- Homopentamer
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
234 residues, UniProt reviewed canonical sequence.
>Q9NXV2|KCTD5
1 MAENHCELLS PARGGIGAGL GGGLCRRCSA GLGALAQRPG SVSKWVRLNV GGTYFLTTRQ
61 TLCRDPKSFL YRLCQADPDL DSDKDETGAY LIDRDPTYFG PVLNYLRHGK LVINKDLAEE
121 GVLEEAEFYN ITSLIKLVKD KIRERDSKTS QVPVKHVYRV LQCQEEELTQ MVSTMSDGWK
181 FEQLVSIGSS YNYGNEDQAE FLCVVSKELH NTPYGTASEP SEKAKILQER GSRMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KCTD5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 34 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 34 nTPM
- colon: 22 nTPM
- lymph node: 20 nTPM
- skin: 19 nTPM
- spleen: 18 nTPM
- liver: 17 nTPM
Single-cell type
- esophageal apical cells: 175 nCPM
- pdcs: 93 nCPM
- colonocytes: 73 nCPM
- megakaryocytes: 68 nCPM
- esophageal suprabasal cells: 59 nCPM
- syncytiotrophoblasts: 51 nCPM
Immune cell
- plasmacytoid DC: 64 nTPM
- eosinophil: 17 nTPM
- myeloid DC: 12 nTPM
- naive B-cell: 7.7 nTPM
- classical monocyte: 7.3 nTPM
- intermediate monocyte: 7.1 nTPM
Brain region
- medulla oblongata: 20 nTPM
- white matter: 19 nTPM
- spinal cord: 19 nTPM
- thalamus: 19 nTPM
- basal ganglia: 17 nTPM
- midbrain: 17 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.79
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 1.19
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of KCTD5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KCTD5 as an antibody target. Whether an autoantibody or antibody against KCTD5 could matter depends on whether native KCTD5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KCTD5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KCTD5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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