KLHL30
Kelch-like protein 30
Also known as: FLJ43374, KLH30_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q0D2K2
- Gene
- KLHL30
- Ensembl
- ENSG00000168427
- Chromosome
- 2
- Canonical length
- 578 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Centriolar satellite
OverviewNCBI Gene
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
578 residues, UniProt reviewed canonical sequence.
>Q0D2K2|KLHL30
1 MVRNVDDLDF HLPSHAQDML DGLQRLRSQP KLADVTLLVG GRELPCHRGL LALSSPYFHA
61 MFAGDFAESF SARVELRDVE PAVVGQLVDF VYTGRLTITQ GNVEALTRTA ARLHFPSVQK
121 VCGRYLQQQL DAANCLGICE FGEQQGLLGV AAKAWAFLRE NFEAVAREDE FLQLPRERLV
181 TCLAGDLLQV QPEQSRLEAL MRWVRHDPQA RAAHLPELLS LVHLDAVPRP CVQQLLASEP
241 LIQESEACRA ALSQGHDGAP LALQQKLEEV LVVVGGQALE EEEAGEEPTP GLGNFAFYNS
301 KAKRWMALPD FPDYHKWGFS LAALNNNIYV TGGSRGTKTD TWSTTQAWCF PLKEASWKPV
361 APMLKPRTNH ASAALNGEIY VIGGTTLDVV EVESYDPYTD SWTPVSPALK YVSNFSAAGC
421 RGRLYLVGSS ACKYNALALQ CYNPVTDAWS VIASPFLPKY LSSPRCAALH GELYLIGDNT
481 KKVYVYDPGA NLWQKVQSQH SLHENGALVP LGDALYVTGG RWQGMEGDYH VEMEAYDTVR
541 DTWTRHGALP RLWLYHGAST VFLDVSKWTQ PSGPTQEHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against KLHL30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.27
- Highest tissue expression
- 141 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 141 nTPM
- tongue: 14 nTPM
- heart muscle: 13 nTPM
- blood vessel: 10 nTPM
- adipose tissue: 3.6 nTPM
- cervix: 1.8 nTPM
Single-cell type
- myonuclei: 30 nCPM
- thymic myoid cells: 23 nCPM
- myosatellite cells: 12 nCPM
- vascular smooth muscle cells: 9.4 nCPM
- cardiomyocytes: 8.5 nCPM
- pericytes: 4 nCPM
Immune cell
- classical monocyte: 0.4 nTPM
- myeloid DC: 0.2 nTPM
- memory B-cell: 0.1 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- medulla oblongata: 2.3 nTPM
- midbrain: 2 nTPM
- cerebellum: 1.2 nTPM
- hypothalamus: 1.2 nTPM
- pons: 0.7 nTPM
- white matter: 0.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.22
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.51
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads KLHL30 as an antibody target. Whether an autoantibody or antibody against KLHL30 could matter depends on whether native KLHL30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
KLHL30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label KLHL30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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