Seroatlas · Human Serome Atlas

KLHL2

Kelch-like protein 2

Also known as: KLHL2_HUMAN, MAV

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95198
Gene
KLHL2
Ensembl
ENSG00000109466
Chromosome
4
Canonical length
593 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

Enables actin binding activity; identical protein binding activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

593 residues, UniProt reviewed canonical sequence.

>O95198|KLHL2
     1  METPPLPPAC TKQGHQKPLD SKDDNTEKHC PVTVNPWHMK KAFKVMNELR SQNLLCDVTI
    61  VAEDMEISAH RVVLAACSPY FHAMFTGEMS ESRAKRVRIK EVDGWTLRML IDYVYTAEIQ
   121  VTEENVQVLL PAAGLLQLQD VKKTCCEFLE SQLHPVNCLG IRAFADMHAC TDLLNKANTY
   181  AEQHFADVVL SEEFLNLGIE QVCSLISSDK LTISSEEKVF EAVIAWVNHD KDVRQEFMAR
   241  LMEHVRLPLL PREYLVQRVE EEALVKNSSA CKDYLIEAMK YHLLPTEQRI LMKSVRTRLR
   301  TPMNLPKLMV VVGGQAPKAI RSVECYDFKE ERWHQVAELP SRRCRAGMVY MAGLVFAVGG
   361  FNGSLRVRTV DSYDPVKDQW TSVANMRDRR STLGAAVLNG LLYAVGGFDG STGLSSVEAY
   421  NIKSNEWFHV APMNTRRSSV GVGVVGGLLY AVGGYDGASR QCLSTVECYN ATTNEWTYIA
   481  EMSTRRSGAG VGVLNNLLYA VGGHDGPLVR KSVEVYDPTT NAWRQVADMN MCRRNAGVCA
   541  VNGLLYVVGG DDGSCNLASV EYYNPTTDKW TVVSSCMSTG RSYAGVTVID KPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
48 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 48 nTPM
  • basal ganglia: 44 nTPM
  • cerebral cortex: 43 nTPM
  • spinal cord: 40 nTPM
  • midbrain: 39 nTPM
  • amygdala: 33 nTPM

Single-cell type

  • neutrophils: 2,386 nCPM
  • esophageal apical cells: 413 nCPM
  • thymic myoid cells: 348 nCPM
  • neutrophil progenitors: 325 nCPM
  • pituicytes/fscs: 257 nCPM
  • breast lactating cells: 230 nCPM

Immune cell

  • neutrophil: 7.2 nTPM
  • basophil: 1.8 nTPM
  • eosinophil: 1.3 nTPM
  • non-classical monocyte: 1.2 nTPM
  • intermediate monocyte: 1 nTPM
  • naive CD8 T-cell: 1 nTPM

Brain region

  • hippocampal formation: 154 nTPM
  • cerebral cortex: 105 nTPM
  • basal ganglia: 96 nTPM
  • white matter: 82 nTPM
  • thalamus: 66 nTPM
  • midbrain: 66 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
3.89
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL2 as an antibody target. Whether an autoantibody or antibody against KLHL2 could matter depends on whether native KLHL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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