ZBTB7A
Zinc finger and BTB domain-containing protein 7A
Also known as: DKFZp547O146, FBI-1, LRF, pokemon, ZBT7A_HUMAN, ZBTB7, ZNF857A
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O95365
- Gene
- ZBTB7A
- Ensembl
- ENSG00000178951
- Chromosome
- 19
- Canonical length
- 584 aa
- Protein class
- Disease related genes, Predicted intracellular proteins, Transcription factors
- Subcellular location
- Nucleoplasm
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Enables several functions, including SMAD binding activity; nuclear androgen receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
584 residues, UniProt reviewed canonical sequence.
>O95365|ZBTB7A
1 MAGGVDGPIG IPFPDHSSDI LSGLNEQRTQ GLLCDVVILV EGREFPTHRS VLAACSQYFK
61 KLFTSGAVVD QQNVYEIDFV SAEALTALMD FAYTATLTVS TANVGDILSA ARLLEIPAVS
121 HVCADLLDRQ ILAADAGADA GQLDLVDQID QRNLLRAKEY LEFFQSNPMN SLPPAAAAAA
181 ASFPWSAFGA SDDDLDATKE AVAAAVAAVA AGDCNGLDFY GPGPPAERPP TGDGDEGDSN
241 PGLWPERDED APTGGLFPPP VAPPAATQNG HYGRGGEEEA ASLSEAAPEP GDSPGFLSGA
301 AEGEDGDGPD VDGLAASTLL QQMMSSVGRA GAAAGDSDEE SRADDKGVMD YYLKYFSGAH
361 DGDVYPAWSQ KVEKKIRAKA FQKCPICEKV IQGAGKLPRH IRTHTGEKPY ECNICKVRFT
421 RQDKLKVHMR KHTGEKPYLC QQCGAAFAHN YDLKNHMRVH TGLRPYQCDS CCKTFVRSDH
481 LHRHLKKDGC NGVPSRRGRK PRVRGGAPDP SPGATATPGA PAQPSSPDAR RNGQEKHFKD
541 EDEDEDVASP DGLGRLNVAG AGGGGDSGGG PGAATDGNFT AGLALocalizationUniProt · AlphaFold · HPA
Whether an antibody against ZBTB7A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 35 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 35 nTPM
- cerebral cortex: 32 nTPM
- skeletal muscle: 31 nTPM
- cerebellum: 29 nTPM
- hippocampal formation: 25 nTPM
- skin: 24 nTPM
Single-cell type
- esophageal apical cells: 233 nCPM
- colonocytes: 209 nCPM
- ocular epithelial cells: 197 nCPM
- suprabasal keratinocytes: 186 nCPM
- prostatic hillock cells: 181 nCPM
- erythrocyte progenitors: 164 nCPM
Immune cell
- neutrophil: 1.5 nTPM
- NK-cell: 1.2 nTPM
- intermediate monocyte: 1.1 nTPM
- memory B-cell: 1.1 nTPM
- non-classical monocyte: 1 nTPM
- classical monocyte: 0.9 nTPM
Brain region
- cerebral cortex: 169 nTPM
- hippocampal formation: 111 nTPM
- white matter: 105 nTPM
- thalamus: 102 nTPM
- amygdala: 97 nTPM
- basal ganglia: 97 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about ZBTB7A.
Disease | AllUniProt
Conditions ZBTB7A is implicated in, by any mechanism.
- Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin (MNDLFH) MIM:619769
Disease | GeneticClinVar
23 pathogenic / likely-pathogenic of 153 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
- Macrocephaly, neurodevelopmental delay, lymphoid hyperplasia, and persistent fetal hemoglobin
- Inborn genetic diseases
- Neurodevelopmental delay
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.33
- gnomAD pLI
- 0.96
- gnomAD missense Z
- 4.04
- DepMap mean gene effect
- -0.25
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- B cell differentiation
- chromatin organization
- chromatin remodeling
- DNA-templated transcription
- double-strand break repair via classical nonhomologous end joining
- erythrocyte maturation
- fat cell differentiation
- negative regulation of androgen receptor signaling pathway
- negative regulation of DNA-templated transcription
- negative regulation of Notch signaling pathway
- negative regulation of transcription by RNA polymerase II
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of NF-kappaB transcription factor activity
- protein localization to nucleus
- regulation of alternative mRNA splicing, via spliceosome
- regulation of apoptotic process
- regulation of DNA-binding transcription factor activity
- regulation of glycolytic process
- regulation of transcription by RNA polymerase II
- regulation of transcription regulatory region DNA binding
Molecular functions
- DNA binding
- DNA-binding transcription factor activity
- DNA-binding transcription factor activity, RNA polymerase II-specific
- DNA-binding transcription factor binding
- DNA-binding transcription repressor activity, RNA polymerase II-specific
- histone acetyltransferase binding
- nuclear androgen receptor binding
- RNA polymerase II cis-regulatory region sequence-specific DNA binding
- sequence-specific double-stranded DNA binding
- SMAD binding
- transcription corepressor binding
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ZBTB7A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ZBTB7A as an antibody target. Whether an autoantibody or antibody against ZBTB7A could matter depends on whether native ZBTB7A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ZBTB7A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label ZBTB7A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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