Seroatlas · Human Serome Atlas

ZBTB24

Zinc finger and BTB domain-containing protein 24

Also known as: BIF1, KIAA0441, PATZ2, ZBT24_HUMAN, ZNF450

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43167
Gene: ZBTB24
Ensembl: ENSG00000112365
Chromosome: 6
Canonical length: 697 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Cytokinetic bridge,Centrosome

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in nucleus. Implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 2. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>O43167|ZBTB24
     1  MAETSPEPSG QLVVHSDAHS DTVLASFEDQ RKKGFLCDIT LIVENVHFRA HKALLAASSE
    61  YFSMMFAEEG EIGQSIYMLE GMVADTFGIL LEFIYTGYLH ASEKSTEQIL ATAQFLKVYD
   121  LVKAYTDFQN NHSSPKPTTL NTAGAPVVVI SNKKNDPPKR KRGRPKKVNT LQEEKSELAA
   181  EEEIQLRVNN SVQNRQNFVV KGDSGVLNEQ IAAKEKEESE PTCEPSREEE MPVEKDENYD
   241  PKTEDGQASQ SRYSKRRIWR SVKLKDYKLV GDQEDHGSAK RICGRRKRPG GPEARCKDCG
   301  KVFKYNHFLA IHQRSHTGER PFKCNECGKG FAQKHSLQVH TRMHTGERPY TCTVCSKALT
   361  TKHSLLEHMS LHSGQKSFTC DQCGKYFSQN RQLKSHYRVH TGHSLPECKD CHRKFMDVSQ
   421  LKKHLRTHTG EKPFTCEICG KSFTAKSSLQ THIRIHRGEK PYSCGICGKS FSDSSAKRRH
   481  CILHTGKKPF SCPECNLQFA RLDNLKAHLK IHSKEKHASD ASSISGSSNT EEVRNILQLQ
   541  PYQLSTSGEQ EIQLLVTDSV HNINFMPGPS QGISIVTAES SQNMTADQAA NLTLLTQQPE
   601  QLQNLILSAQ QEQTEHIQSL NMIESQMGPS QTEPVHVITL SKETLEHLHA HQEQTEELHL
   661  ATSTSDPAQH LQLTQEPGPP PPTHHVPQPT PLGQEQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 17 nTPM
retina: 6.7 nTPM
lymph node: 6.6 nTPM
parathyroid gland: 5.6 nTPM
tonsil: 5.4 nTPM
thymus: 5.2 nTPM

Single-cell type

rod photoreceptor cells: 46 nCPM
b-cells: 32 nCPM
differentiating spermatogonia: 28 nCPM
undifferentiated spermatogonia: 21 nCPM
thymocytes: 20 nCPM
t-cells: 19 nCPM

Immune cell

memory B-cell: 4.8 nTPM
T-reg: 4.1 nTPM
naive B-cell: 3.6 nTPM
naive CD4 T-cell: 2.3 nTPM
memory CD4 T-cell: 2.1 nTPM
NK-cell: 1.7 nTPM

Brain region

white matter: 8.2 nTPM
cerebellum: 7.7 nTPM
basal ganglia: 7 nTPM
cerebral cortex: 6.9 nTPM
hypothalamus: 6.7 nTPM
pons: 6.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZBTB24.

Disease | AllUniProt

Conditions ZBTB24 is implicated in, by any mechanism.

Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2) MIM:614069

Disease | GeneticClinVar

54 pathogenic / likely-pathogenic of 544 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Immunodeficiency-centromeric instability-facial anomalies syndrome 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZBTB24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB24 as an antibody target. Whether an autoantibody or antibody against ZBTB24 could matter depends on whether native ZBTB24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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