Seroatlas · Human Serome Atlas

BTBD6

BTB/POZ domain-containing protein 6

Also known as: BDPL, BTBD6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96KE9
Gene
BTBD6
Ensembl
ENSG00000184887
Chromosome
14
Canonical length
538 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in neurogenesis. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

538 residues, UniProt reviewed canonical sequence.

>Q96KE9|BTBD6
     1  MLLPLACLHG RVAQCLTSLL LLAEPLPRPR RGARARGAAS TGAEAAPAAP PAKMAAELYA
    61  PASAAAADLA NSNAGAAVGR KAGPRSPPSA PAPAPPPPAP APPTLGNNHQ ESPGWRCCRP
   121  TLRERNALMF NNELMADVHF VVGPPGATRT VPAHKYVLAV GSSVFYAMFY GDLAEVKSEI
   181  HIPDVEPAAF LILLKYMYSD EIDLEADTVL ATLYAAKKYI VPALAKACVN FLETSLEAKN
   241  ACVLLSQSRL FEEPELTQRC WEVIDAQAEM ALRSEGFCEI DRQTLEIIVT REALNTKEAV
   301  VFEAVLNWAE AECKRQGLPI TPRNKRHVLG RALYLVRIPT MTLEEFANGA AQSDILTLEE
   361  THSIFLWYTA TNKPRLDFPL TKRKGLAPQR CHRFQSSAYR SNQWRYRGRC DSIQFAVDRR
   421  VFIAGLGLYG SSSGKAEYSV KIELKRLGVV LAQNLTKFMS DGSSNTFPVW FEHPVQVEQD
   481  TFYTASAVLD GSELSYFGQE GMTEVQCGKV AFQFQCSSDS TNGTGVQGGQ IPELIFYA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTBD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
154 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 154 nTPM
  • tongue: 133 nTPM
  • testis: 75 nTPM
  • cerebral cortex: 69 nTPM
  • adipose tissue: 65 nTPM
  • amygdala: 61 nTPM

Single-cell type

  • megakaryocytes: 204 nCPM
  • platelets: 103 nCPM
  • late spermatids: 59 nCPM
  • endometrial glandular cells: 42 nCPM
  • breast lactating cells: 41 nCPM
  • alveolar cells type 1: 39 nCPM

Immune cell

  • T-reg: 5.2 nTPM
  • eosinophil: 2.9 nTPM
  • memory CD4 T-cell: 2.4 nTPM
  • memory CD8 T-cell: 2.3 nTPM
  • gdT-cell: 2.2 nTPM
  • MAIT T-cell: 2.2 nTPM

Brain region

  • cerebral cortex: 43 nTPM
  • hippocampal formation: 38 nTPM
  • basal ganglia: 34 nTPM
  • hypothalamus: 34 nTPM
  • amygdala: 34 nTPM
  • white matter: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.06
gnomAD pLI
0
gnomAD missense Z
0.82
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BTBD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTBD6 as an antibody target. Whether an autoantibody or antibody against BTBD6 could matter depends on whether native BTBD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTBD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTBD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BTBD6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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