Seroatlas · Human Serome Atlas

ELOC

Elongin-C

Also known as: ELOC_HUMAN, SIII, TCEB1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15369
Gene
ELOC
Ensembl
ENSG00000154582
Chromosome
8
Canonical length
112 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoli,Vesicles,Cell Junctions

OverviewNCBI Gene

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Canonical amino-acid sequenceUniProt

112 residues, UniProt reviewed canonical sequence.

>Q15369|ELOC
     1  MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG QFAENETNEV
    61  NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA LELLMAANFL DC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ELOC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
191 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 191 nTPM
  • heart muscle: 138 nTPM
  • tongue: 121 nTPM
  • cerebral cortex: 118 nTPM
  • testis: 112 nTPM
  • amygdala: 111 nTPM

Single-cell type

  • esophageal apical cells: 992 nCPM
  • late primary spermatocytes: 919 nCPM
  • early spermatids: 636 nCPM
  • late spermatids: 588 nCPM
  • extravillous trophoblasts: 445 nCPM
  • esophageal suprabasal cells: 439 nCPM

Immune cell

  • basophil: 144 nTPM
  • plasmacytoid DC: 124 nTPM
  • T-reg: 103 nTPM
  • eosinophil: 89 nTPM
  • memory B-cell: 87 nTPM
  • neutrophil: 82 nTPM

Brain region

  • cerebral cortex: 88 nTPM
  • hippocampal formation: 85 nTPM
  • white matter: 82 nTPM
  • basal ganglia: 80 nTPM
  • cerebellum: 79 nTPM
  • hypothalamus: 76 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ELOC.

Disease | ImmuneIEDB

Conditions an epitope on ELOC was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.66
gnomAD pLI
0.74
DepMap mean gene effect
-1.25
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ELOC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ELOC as an antibody target. Whether an autoantibody or antibody against ELOC could matter depends on whether native ELOC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ELOC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ELOC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ELOC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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