Seroatlas · Human Serome Atlas

ZBTB39

Zinc finger and BTB domain-containing protein 39

Also known as: KIAA0352, ZBT39_HUMAN, ZNF922

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15060
Gene
ZBTB39
Ensembl
ENSG00000166860
Chromosome
12
Canonical length
712 aa
Protein class
Predicted intracellular proteins, Transcription factors
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

712 residues, UniProt reviewed canonical sequence.

>O15060|ZBTB39
     1  MGMRIKLQST NHPNNLLKEL NKCRLSETMC DVTIVVGSRS FPAHKAVLAC AAGYFQNLFL
    61  NTGLDAARTY VVDFITPANF EKVLSFVYTS ELFTDLINVG VIYEVAERLG MEDLLQACHS
   121  TFPDLESTAR AKPLTSTSES HSGTLSCPSA EPAHPLGELR GGGDYLGADR NYVLPSDAGG
   181  SYKEEEKNVA SDANHSLHLP QPPPPPPKTE DHDTPAPFTS IPSMMTQPLL GTVSTGIQTS
   241  TSSCQPYKVQ SNGDFSKNSF LTPDNAVDIT TGTNSCLSNS EHSKDPGFGQ MDELQLEDLG
   301  DDDLQFEDPA EDIGTTEEVI ELSDDSEDEL AFGENDNREN KAMPCQVCKK VLEPNIQLIR
   361  QHARDHVDLL TGNCKVCETH FQDRNSRVTH VLSHIGIFLF SCDMCETKFF TQWQLTLHRR
   421  DGIFENNIIV HPNDPLPGKL GLFSGAASPE LKCAACGKVL AKDFHVVRGH ILDHLNLKGQ
   481  ACSVCDQRHL NLCSLMWHTL SHLGISVFSC SVCANSFVDW HLLEKHMAVH QSLEDALFHC
   541  RLCSQSFKSE AAYRYHVSQH KCNSGLDARP GFGLQHPALQ KRKLPAEEFL GEELALQGQP
   601  GNSKYSCKVC GKRFAHTSEF NYHRRIHTGE KPYQCKVCHK FFRGRSTIKC HLKTHSGALM
   661  YRCTVCGHYS STLNLMSKHV GVHKGSLPPD FTIEQTFMYI IHSKEADKNP DS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZBTB39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
6.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.6 nTPM
  • bone marrow: 5.5 nTPM
  • spleen: 3.9 nTPM
  • thymus: 3.9 nTPM
  • lymph node: 3.6 nTPM
  • placenta: 3.5 nTPM

Single-cell type

  • late spermatids: 31 nCPM
  • early spermatids: 30 nCPM
  • differentiating spermatogonia: 21 nCPM
  • retinal horizontal cells: 16 nCPM
  • early primary spermatocytes: 16 nCPM
  • undifferentiated spermatogonia: 10 nCPM

Immune cell

  • basophil: 0.7 nTPM
  • NK-cell: 0.7 nTPM
  • memory CD8 T-cell: 0.6 nTPM
  • naive CD8 T-cell: 0.6 nTPM
  • plasmacytoid DC: 0.5 nTPM
  • gdT-cell: 0.4 nTPM

Brain region

  • cerebellum: 6.2 nTPM
  • white matter: 6.2 nTPM
  • basal ganglia: 5.9 nTPM
  • midbrain: 5.9 nTPM
  • cerebral cortex: 5.8 nTPM
  • thalamus: 5.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
-0.09
DepMap mean gene effect
-0.29
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZBTB39 as an antibody target. Whether an autoantibody or antibody against ZBTB39 could matter depends on whether native ZBTB39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZBTB39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZBTB39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZBTB39. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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