Seroatlas · Human Serome Atlas

KLHL36

Kelch-like protein 36

Also known as: C16orf44, FLJ12543, KLH36_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N4N3
Gene
KLHL36
Ensembl
ENSG00000135686
Chromosome
16
Canonical length
616 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables cullin family protein binding activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

616 residues, UniProt reviewed canonical sequence.

>Q8N4N3|KLHL36
     1  MMEGSRQTRV SRPYKISESS KVYRWADHSS TVLQRLNEQR LRGLFCDVVL VADEQRVPAH
    61  RNLLAVCSDY FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELV LDGGNIDYVL
   121  ETAHLLQIWT VVDFCCEYLE QEVSEDNYLY LQELASIYSL KRLDAFIDGF ILNHFGTLSF
   181  TPDFLQNVSM QKLCVYLSSS EVQRECEHDL LQAALQWLTQ QPEREAHARQ VLENIHFPLI
   241  PKNDLLHRVK PAVCSLLPKE ANCEGFIEEA VRYHNNLAAQ PVMQTKRTAL RTNQERLLFV
   301  GGEVSERCLE LSDDTCYLDA KSEQWVKETP LPARRSHHCV AVLGGFIFIA GGSFSRDNGG
   361  DAASNLLYRY DPRCKQWIKV ASMNQRRVDF YLASIEDMLV AIGGRNENGA LSSVETYSPK
   421  TDSWSYVAGL PRFTYGHAGT IYKDFVYISG GHDYQIGPYR KNLLCYDHRT DVWEERRPMT
   481  TARGWHSMCS LGDSIYSIGG SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG
   541  VAVWEGRIYI LGGYSWENTA FSKTVQVYDR EADKWSRGVD LPKAIAGGSA CVCALEPRPE
   601  DKKKKGKGKR HQDRGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KLHL36 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • testis: 13 nTPM
  • bone marrow: 13 nTPM
  • blood vessel: 12 nTPM
  • pancreas: 11 nTPM
  • liver: 10 nTPM
  • heart muscle: 10 nTPM

Single-cell type

  • proximal tubule cells: 58 nCPM
  • sertoli cells: 53 nCPM
  • parietal cells: 51 nCPM
  • late primary spermatocytes: 51 nCPM
  • tuft cells: 46 nCPM
  • adrenal cortex cells: 46 nCPM

Immune cell

  • naive CD4 T-cell: 6.9 nTPM
  • eosinophil: 6.3 nTPM
  • memory CD4 T-cell: 5.9 nTPM
  • naive CD8 T-cell: 5 nTPM
  • memory CD8 T-cell: 4.7 nTPM
  • memory B-cell: 4.5 nTPM

Brain region

  • choroid plexus: 34 nTPM
  • hippocampal formation: 32 nTPM
  • amygdala: 28 nTPM
  • cerebral cortex: 28 nTPM
  • medulla oblongata: 27 nTPM
  • thalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.4
gnomAD pLI
0.81
gnomAD missense Z
1.12
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KLHL36 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KLHL36 as an antibody target. Whether an autoantibody or antibody against KLHL36 could matter depends on whether native KLHL36 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KLHL36 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KLHL36 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KLHL36. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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