Seroatlas · Human Serome Atlas

KCNG4

Voltage-gated potassium channel regulatory subunit KCNG4

Also known as: KCNG4_HUMAN, Kv6.4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDN1
Gene
KCNG4
Ensembl
ENSG00000168418
Chromosome
16
Canonical length
519 aa
Protein class
Predicted membrane proteins, Transporters, Voltage-gated ion channels
Subcellular location
Nucleoplasm,Plasma membrane
Quaternary structure
Homomultimer

OverviewNCBI Gene

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q8TDN1|KCNG4
     1  MPMPSRDGGL HPRHHHYGSH SPWSQLLSSP METPSIKGLY YRRVRKVGAL DASPVDLKKE
    61  ILINVGGRRY LLPWSTLDRF PLSRLSKLRL CRSYEEIVQL CDDYDEDSQE FFFDRSPSAF
   121  GVIVSFLAAG KLVLLQEMCA LSFQEELAYW GIEEAHLERC CLRKLLRKLE ELEELAKLHR
   181  EDVLRQQRET RRPASHSSRW GLCMNRLREM VENPQSGLPG KVFACLSILF VATTAVSLCV
   241  STMPDLRAEE DQGECSRKCY YIFIVETICV AWFSLEFCLR FVQAQDKCQF FQGPLNIIDI
   301  LAISPYYVSL AVSEEPPEDG ERPSGSSYLE KVGLVLRVLR ALRILYVMRL ARHSLGLQTL
   361  GLTVRRCTRE FGLLLLFLAV AITLFSPLVY VAEKESGRVL EFTSIPASYW WAIISMTTVG
   421  YGDMVPRSVP GQMVALSSIL SGILIMAFPA TSIFHTFSHS YLELKKEQEQ LQARLRHLQN
   481  TGPASECELL DPHVASEHEL MNDVNDLILE GPALPIMHM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
3.6 nTPM

Expression across tissuesHPA

Tissue

  • retina: 3.6 nTPM
  • midbrain: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • hippocampal formation: 0.5 nTPM
  • hypothalamus: 0.4 nTPM
  • adrenal gland: 0.3 nTPM

Single-cell type

  • retinal bipolar cells: 74 nCPM
  • oligodendrocyte progenitor cells: 12 nCPM
  • thyrotrophs: 7.8 nCPM
  • retinal ganglion cells: 3.9 nCPM
  • epicardial cells: 2.3 nCPM
  • müller glia: 2.3 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • neutrophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • medulla oblongata: 8.4 nTPM
  • cerebellum: 8.2 nTPM
  • pons: 6.4 nTPM
  • midbrain: 4.7 nTPM
  • spinal cord: 4.4 nTPM
  • white matter: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.89
gnomAD pLI
0
gnomAD missense Z
-1.66
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNG4 as an antibody target. Whether an autoantibody or antibody against KCNG4 could matter depends on whether native KCNG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNG4 is annotated at the cell surface, where native KCNG4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNG4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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