Seroatlas · Human Serome Atlas

BTBD16

BTB/POZ domain-containing protein 16

Also known as: BTBDG_HUMAN, C10orf87, Em:AC061711.1, FLJ25359

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q32M84
Gene: BTBD16
Ensembl: ENSG00000138152
Chromosome: 10
Canonical length: 506 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

This gene encodes a protein that contains a BTB/POZ domain. This domain mediates protein-protein interactions. A mutation in this gene may be associated with bipolar disorder. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

506 residues, UniProt reviewed canonical sequence.

>Q32M84|BTBD16
     1  MIMSNTHKAR LERRVTGSTN RWRLPKQPFS GDLLSLSQMC KALSIDFEEA LRNPDRLCIS
    61  QIQKFFFENF KNKDIQSGEA DVILECLGFK WELHQPQLFQ SETLAKLYLK ALAQGTTHPL
   121  RELEELLRAQ SPKKTKEKSP AKRIIISLKI NDPLVTKVAF ATALKNLYMS EVEINLEDLL
   181  GVLASAHILQ FSGLFQRCVD VMIARLKPST IKKFYEAGCK YKEEQLTTGC EKWLEMNLVP
   241  LGGTQIHLHK IPQDLLHKVL KSPRLFTFSE FHLLKTMLLW VFLQLNYKIQ AIPTYETVMT
   301  FFKSFPENCC FLDRDIGRSL RPLFLCLRLH GITKGKDLEV LRHLNFFPES WLDQVTVNHY
   361  HALENGGDMV HLKDLNTQAV RFGLLFNQEN TTYSKTIALY GFFFKIKGLK HDTTSYSFYM
   421  QRIKHTDLES PSAVYEHNHV SLRAARLVKY EIRAEALVDG KWQEFRTNQI KQKFGLTTSS
   481  CKSHTLKIQT VGIPIYVSFA FIFPAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTBD16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 19 nTPM
skin: 7.9 nTPM
testis: 7.3 nTPM
liver: 3.8 nTPM
spinal cord: 2.8 nTPM
midbrain: 1.6 nTPM

Single-cell type

urothelial cells: 256 nCPM
early spermatids: 119 nCPM
late primary spermatocytes: 88 nCPM
late spermatids: 86 nCPM
alveolar cells type 2: 55 nCPM
papillary tip epithelial cells: 29 nCPM

Immune cell

T-reg: 0.6 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 3.1 nTPM
pons: 1.8 nTPM
basal ganglia: 1.6 nTPM
cerebral cortex: 1.6 nTPM
medulla oblongata: 1.6 nTPM
midbrain: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

SKP1/BTB/POZ domain superfamily
BTB/POZ domain-containing protein 16
BTB/POZ domain-containing protein 16, C-terminal domain
BTBDG, BTB/POZ domain
BTB/POZ domain-containing protein 16, C-terminal domain
BTBDG BTB/POZ domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTBD16 as an antibody target. Whether an autoantibody or antibody against BTBD16 could matter depends on whether native BTBD16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTBD16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BTBD16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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